New Insight into Molecular and Hormonal Connection in Andrology

Hormones and cytokines are known to regulate cellular functions in the testes. These biomolecules induce a broad spectrum of effects on various level of spermatogenesis, and among them is the modulation of cell junction restructuring between Sertoli cells and germ cells in the seminiferous epitheliu...

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Autores principales:	Davide Francomano, Valerio Sanguigni, Paolo Capogrosso, Federico Deho, Gabriele Antonini
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cytokines testosterone testicular function miRNAs EPCS Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/ab5ad5881f554068aaaed5e2458f3cac
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spelling	oai:doaj.org-article:ab5ad5881f554068aaaed5e2458f3cac2021-11-11T17:19:32ZNew Insight into Molecular and Hormonal Connection in Andrology10.3390/ijms2221119081422-00671661-6596https://doaj.org/article/ab5ad5881f554068aaaed5e2458f3cac2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11908https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Hormones and cytokines are known to regulate cellular functions in the testes. These biomolecules induce a broad spectrum of effects on various level of spermatogenesis, and among them is the modulation of cell junction restructuring between Sertoli cells and germ cells in the seminiferous epithelium. Cytokines and androgens are closely related, and both correct testicular development and the maintenance of spermatogenesis depend on their function. Cytokines also play a crucial role in the immune testicular system, activating and directing leucocytes across the endothelial barrier to the inflammatory site, as well as in increasing their adhesion to the vascular wall. The purpose of this review is to revise the most recent findings on molecular mechanisms that play a key role in male sexual function, focusing on three specific molecular patterns, namely, cytokines, miRNAs, and endothelial progenitor cells. Numerous reports on the interactions between the immune and endocrine systems can be found in the literature. However, there is not yet a multi-approach review of the literature underlying the role between molecular patterns and testicular and sexual function.Davide FrancomanoValerio SanguigniPaolo CapogrossoFederico DehoGabriele AntoniniMDPI AGarticlecytokinestestosteronetesticular functionmiRNAsEPCSBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11908, p 11908 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cytokines testosterone testicular function miRNAs EPCS Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	cytokines testosterone testicular function miRNAs EPCS Biology (General) QH301-705.5 Chemistry QD1-999 Davide Francomano Valerio Sanguigni Paolo Capogrosso Federico Deho Gabriele Antonini New Insight into Molecular and Hormonal Connection in Andrology
description	Hormones and cytokines are known to regulate cellular functions in the testes. These biomolecules induce a broad spectrum of effects on various level of spermatogenesis, and among them is the modulation of cell junction restructuring between Sertoli cells and germ cells in the seminiferous epithelium. Cytokines and androgens are closely related, and both correct testicular development and the maintenance of spermatogenesis depend on their function. Cytokines also play a crucial role in the immune testicular system, activating and directing leucocytes across the endothelial barrier to the inflammatory site, as well as in increasing their adhesion to the vascular wall. The purpose of this review is to revise the most recent findings on molecular mechanisms that play a key role in male sexual function, focusing on three specific molecular patterns, namely, cytokines, miRNAs, and endothelial progenitor cells. Numerous reports on the interactions between the immune and endocrine systems can be found in the literature. However, there is not yet a multi-approach review of the literature underlying the role between molecular patterns and testicular and sexual function.
format	article
author	Davide Francomano Valerio Sanguigni Paolo Capogrosso Federico Deho Gabriele Antonini
author_facet	Davide Francomano Valerio Sanguigni Paolo Capogrosso Federico Deho Gabriele Antonini
author_sort	Davide Francomano
title	New Insight into Molecular and Hormonal Connection in Andrology
title_short	New Insight into Molecular and Hormonal Connection in Andrology
title_full	New Insight into Molecular and Hormonal Connection in Andrology
title_fullStr	New Insight into Molecular and Hormonal Connection in Andrology
title_full_unstemmed	New Insight into Molecular and Hormonal Connection in Andrology
title_sort	new insight into molecular and hormonal connection in andrology
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ab5ad5881f554068aaaed5e2458f3cac
work_keys_str_mv	AT davidefrancomano newinsightintomolecularandhormonalconnectioninandrology AT valeriosanguigni newinsightintomolecularandhormonalconnectioninandrology AT paolocapogrosso newinsightintomolecularandhormonalconnectioninandrology AT federicodeho newinsightintomolecularandhormonalconnectioninandrology AT gabrieleantonini newinsightintomolecularandhormonalconnectioninandrology
_version_	1718432138391453696

New Insight into Molecular and Hormonal Connection in Andrology

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