Faecal microbiota transplantation for the treatment of diarrhoea induced by tyrosine-kinase inhibitors in patients with metastatic renal cell carcinoma

Tyrosine kinase inhibitors (TKIs) have improved the clinical outcomes of patients with metastatic renal cell carcinoma (mRCC), however TKI-related diarrhoea is a common and serious adverse effect. Here the authors show in a randomized clinical trial that faecal microbiota transplantation from health...

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Autores principales:	Gianluca Ianiro, Ernesto Rossi, Andrew M. Thomas, Giovanni Schinzari, Luca Masucci, Gianluca Quaranta, Carlo Romano Settanni, Loris Riccardo Lopetuso, Federica Armanini, Aitor Blanco-Miguez, Francesco Asnicar, Clarissa Consolandi, Roberto Iacovelli, Maurizio Sanguinetti, Giampaolo Tortora, Antonio Gasbarrini, Nicola Segata, Giovanni Cammarota
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ab5ae20fc58c49258c28693a84568fb9
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spelling	oai:doaj.org-article:ab5ae20fc58c49258c28693a84568fb92021-12-02T15:09:26ZFaecal microbiota transplantation for the treatment of diarrhoea induced by tyrosine-kinase inhibitors in patients with metastatic renal cell carcinoma10.1038/s41467-020-18127-y2041-1723https://doaj.org/article/ab5ae20fc58c49258c28693a84568fb92020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18127-yhttps://doaj.org/toc/2041-1723Tyrosine kinase inhibitors (TKIs) have improved the clinical outcomes of patients with metastatic renal cell carcinoma (mRCC), however TKI-related diarrhoea is a common and serious adverse effect. Here the authors show in a randomized clinical trial that faecal microbiota transplantation from healthy donors can improve TKI-induced diarrhoea in patients with mRCC.Gianluca IaniroErnesto RossiAndrew M. ThomasGiovanni SchinzariLuca MasucciGianluca QuarantaCarlo Romano SettanniLoris Riccardo LopetusoFederica ArmaniniAitor Blanco-MiguezFrancesco AsnicarClarissa ConsolandiRoberto IacovelliMaurizio SanguinettiGiampaolo TortoraAntonio GasbarriniNicola SegataGiovanni CammarotaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-6 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gianluca Ianiro Ernesto Rossi Andrew M. Thomas Giovanni Schinzari Luca Masucci Gianluca Quaranta Carlo Romano Settanni Loris Riccardo Lopetuso Federica Armanini Aitor Blanco-Miguez Francesco Asnicar Clarissa Consolandi Roberto Iacovelli Maurizio Sanguinetti Giampaolo Tortora Antonio Gasbarrini Nicola Segata Giovanni Cammarota Faecal microbiota transplantation for the treatment of diarrhoea induced by tyrosine-kinase inhibitors in patients with metastatic renal cell carcinoma
description	Tyrosine kinase inhibitors (TKIs) have improved the clinical outcomes of patients with metastatic renal cell carcinoma (mRCC), however TKI-related diarrhoea is a common and serious adverse effect. Here the authors show in a randomized clinical trial that faecal microbiota transplantation from healthy donors can improve TKI-induced diarrhoea in patients with mRCC.
format	article
author	Gianluca Ianiro Ernesto Rossi Andrew M. Thomas Giovanni Schinzari Luca Masucci Gianluca Quaranta Carlo Romano Settanni Loris Riccardo Lopetuso Federica Armanini Aitor Blanco-Miguez Francesco Asnicar Clarissa Consolandi Roberto Iacovelli Maurizio Sanguinetti Giampaolo Tortora Antonio Gasbarrini Nicola Segata Giovanni Cammarota
author_facet	Gianluca Ianiro Ernesto Rossi Andrew M. Thomas Giovanni Schinzari Luca Masucci Gianluca Quaranta Carlo Romano Settanni Loris Riccardo Lopetuso Federica Armanini Aitor Blanco-Miguez Francesco Asnicar Clarissa Consolandi Roberto Iacovelli Maurizio Sanguinetti Giampaolo Tortora Antonio Gasbarrini Nicola Segata Giovanni Cammarota
author_sort	Gianluca Ianiro
title	Faecal microbiota transplantation for the treatment of diarrhoea induced by tyrosine-kinase inhibitors in patients with metastatic renal cell carcinoma
title_short	Faecal microbiota transplantation for the treatment of diarrhoea induced by tyrosine-kinase inhibitors in patients with metastatic renal cell carcinoma
title_full	Faecal microbiota transplantation for the treatment of diarrhoea induced by tyrosine-kinase inhibitors in patients with metastatic renal cell carcinoma
title_fullStr	Faecal microbiota transplantation for the treatment of diarrhoea induced by tyrosine-kinase inhibitors in patients with metastatic renal cell carcinoma
title_full_unstemmed	Faecal microbiota transplantation for the treatment of diarrhoea induced by tyrosine-kinase inhibitors in patients with metastatic renal cell carcinoma
title_sort	faecal microbiota transplantation for the treatment of diarrhoea induced by tyrosine-kinase inhibitors in patients with metastatic renal cell carcinoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ab5ae20fc58c49258c28693a84568fb9
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Faecal microbiota transplantation for the treatment of diarrhoea induced by tyrosine-kinase inhibitors in patients with metastatic renal cell carcinoma

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