Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis

Ciliogenesis is a complex process requiring hundreds of molecules, although few secreted proteins have been implicated. Here, the authors show that the secreted metalloproteases ADAMTS9 and ADAMTS20 intracellularly regulate ciliogenesis from unique periciliary vesicles with proteolytic activity.

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Autores principales:	Sumeda Nandadasa, Caroline M. Kraft, Lauren W. Wang, Anna O’Donnell, Rushabh Patel, Heon Yung Gee, Kay Grobe, Timothy C. Cox, Friedhelm Hildebrandt, Suneel S. Apte
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ab5baac1ec5848ec9b9f690a16ccfcb8
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spelling	oai:doaj.org-article:ab5baac1ec5848ec9b9f690a16ccfcb82021-12-02T16:57:06ZSecreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis10.1038/s41467-019-08520-72041-1723https://doaj.org/article/ab5baac1ec5848ec9b9f690a16ccfcb82019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08520-7https://doaj.org/toc/2041-1723Ciliogenesis is a complex process requiring hundreds of molecules, although few secreted proteins have been implicated. Here, the authors show that the secreted metalloproteases ADAMTS9 and ADAMTS20 intracellularly regulate ciliogenesis from unique periciliary vesicles with proteolytic activity.Sumeda NandadasaCaroline M. KraftLauren W. WangAnna O’DonnellRushabh PatelHeon Yung GeeKay GrobeTimothy C. CoxFriedhelm HildebrandtSuneel S. ApteNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sumeda Nandadasa Caroline M. Kraft Lauren W. Wang Anna O’Donnell Rushabh Patel Heon Yung Gee Kay Grobe Timothy C. Cox Friedhelm Hildebrandt Suneel S. Apte Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis
description	Ciliogenesis is a complex process requiring hundreds of molecules, although few secreted proteins have been implicated. Here, the authors show that the secreted metalloproteases ADAMTS9 and ADAMTS20 intracellularly regulate ciliogenesis from unique periciliary vesicles with proteolytic activity.
format	article
author	Sumeda Nandadasa Caroline M. Kraft Lauren W. Wang Anna O’Donnell Rushabh Patel Heon Yung Gee Kay Grobe Timothy C. Cox Friedhelm Hildebrandt Suneel S. Apte
author_facet	Sumeda Nandadasa Caroline M. Kraft Lauren W. Wang Anna O’Donnell Rushabh Patel Heon Yung Gee Kay Grobe Timothy C. Cox Friedhelm Hildebrandt Suneel S. Apte
author_sort	Sumeda Nandadasa
title	Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis
title_short	Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis
title_full	Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis
title_fullStr	Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis
title_full_unstemmed	Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis
title_sort	secreted metalloproteases adamts9 and adamts20 have a non-canonical role in ciliary vesicle growth during ciliogenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ab5baac1ec5848ec9b9f690a16ccfcb8
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Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis

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