NeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins

Covalent conjugation of endogenous protein complexes offers many opportunities for fundamental and clinical research. Based on a bacterial protein domain that forms a reactive anhydride in the presence of Ca2+, the authors here develop a system that enables the covalent capture of endogenous binding...

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Autores principales:	Arne H. A. Scheu, Sheryl Y. T. Lim, Felix J. Metzner, Shabaz Mohammed, Mark Howarth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ab5f138f64dd46278658c6e3480f8611
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spelling	oai:doaj.org-article:ab5f138f64dd46278658c6e3480f86112021-12-02T14:16:13ZNeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins10.1038/s41467-021-20963-52041-1723https://doaj.org/article/ab5f138f64dd46278658c6e3480f86112021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20963-5https://doaj.org/toc/2041-1723Covalent conjugation of endogenous protein complexes offers many opportunities for fundamental and clinical research. Based on a bacterial protein domain that forms a reactive anhydride in the presence of Ca2+, the authors here develop a system that enables the covalent capture of endogenous binding partners.Arne H. A. ScheuSheryl Y. T. LimFelix J. MetznerShabaz MohammedMark HowarthNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Arne H. A. Scheu Sheryl Y. T. Lim Felix J. Metzner Shabaz Mohammed Mark Howarth NeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins
description	Covalent conjugation of endogenous protein complexes offers many opportunities for fundamental and clinical research. Based on a bacterial protein domain that forms a reactive anhydride in the presence of Ca2+, the authors here develop a system that enables the covalent capture of endogenous binding partners.
format	article
author	Arne H. A. Scheu Sheryl Y. T. Lim Felix J. Metzner Shabaz Mohammed Mark Howarth
author_facet	Arne H. A. Scheu Sheryl Y. T. Lim Felix J. Metzner Shabaz Mohammed Mark Howarth
author_sort	Arne H. A. Scheu
title	NeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins
title_short	NeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins
title_full	NeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins
title_fullStr	NeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins
title_full_unstemmed	NeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins
title_sort	neisslock provides an inducible protein anhydride for covalent targeting of endogenous proteins
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ab5f138f64dd46278658c6e3480f8611
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NeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins

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