NeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins

Covalent conjugation of endogenous protein complexes offers many opportunities for fundamental and clinical research. Based on a bacterial protein domain that forms a reactive anhydride in the presence of Ca2+, the authors here develop a system that enables the covalent capture of endogenous binding...

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Autores principales: Arne H. A. Scheu, Sheryl Y. T. Lim, Felix J. Metzner, Shabaz Mohammed, Mark Howarth
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/ab5f138f64dd46278658c6e3480f8611
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