NeissLock provides an inducible protein anhydride for covalent targeting of endogenous proteins
Covalent conjugation of endogenous protein complexes offers many opportunities for fundamental and clinical research. Based on a bacterial protein domain that forms a reactive anhydride in the presence of Ca2+, the authors here develop a system that enables the covalent capture of endogenous binding...
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Autores principales: | Arne H. A. Scheu, Sheryl Y. T. Lim, Felix J. Metzner, Shabaz Mohammed, Mark Howarth |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/ab5f138f64dd46278658c6e3480f8611 |
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