Cardiac sodium channel palmitoylation regulates channel availability and myocyte excitability with implications for arrhythmia generation

Cardiac voltage-gated sodium channels (Nav1.5) are crucial regulators of heart electric activity. Here the authors show that palmitoylation, a process of lipid modification of cysteine residues, modulates Nav1.5 function and affects cardiomyocyte excitability, representing a potential target in trea...

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Autores principales:	Zifan Pei, Yucheng Xiao, Jingwei Meng, Andy Hudmon, Theodore R. Cummins
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ab603083dedd44c1938573e6d1f39389
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spelling	oai:doaj.org-article:ab603083dedd44c1938573e6d1f393892021-12-02T14:39:52ZCardiac sodium channel palmitoylation regulates channel availability and myocyte excitability with implications for arrhythmia generation10.1038/ncomms120352041-1723https://doaj.org/article/ab603083dedd44c1938573e6d1f393892016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms12035https://doaj.org/toc/2041-1723Cardiac voltage-gated sodium channels (Nav1.5) are crucial regulators of heart electric activity. Here the authors show that palmitoylation, a process of lipid modification of cysteine residues, modulates Nav1.5 function and affects cardiomyocyte excitability, representing a potential target in treating cardiac diseases.Zifan PeiYucheng XiaoJingwei MengAndy HudmonTheodore R. CumminsNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zifan Pei Yucheng Xiao Jingwei Meng Andy Hudmon Theodore R. Cummins Cardiac sodium channel palmitoylation regulates channel availability and myocyte excitability with implications for arrhythmia generation
description	Cardiac voltage-gated sodium channels (Nav1.5) are crucial regulators of heart electric activity. Here the authors show that palmitoylation, a process of lipid modification of cysteine residues, modulates Nav1.5 function and affects cardiomyocyte excitability, representing a potential target in treating cardiac diseases.
format	article
author	Zifan Pei Yucheng Xiao Jingwei Meng Andy Hudmon Theodore R. Cummins
author_facet	Zifan Pei Yucheng Xiao Jingwei Meng Andy Hudmon Theodore R. Cummins
author_sort	Zifan Pei
title	Cardiac sodium channel palmitoylation regulates channel availability and myocyte excitability with implications for arrhythmia generation
title_short	Cardiac sodium channel palmitoylation regulates channel availability and myocyte excitability with implications for arrhythmia generation
title_full	Cardiac sodium channel palmitoylation regulates channel availability and myocyte excitability with implications for arrhythmia generation
title_fullStr	Cardiac sodium channel palmitoylation regulates channel availability and myocyte excitability with implications for arrhythmia generation
title_full_unstemmed	Cardiac sodium channel palmitoylation regulates channel availability and myocyte excitability with implications for arrhythmia generation
title_sort	cardiac sodium channel palmitoylation regulates channel availability and myocyte excitability with implications for arrhythmia generation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ab603083dedd44c1938573e6d1f39389
work_keys_str_mv	AT zifanpei cardiacsodiumchannelpalmitoylationregulateschannelavailabilityandmyocyteexcitabilitywithimplicationsforarrhythmiageneration AT yuchengxiao cardiacsodiumchannelpalmitoylationregulateschannelavailabilityandmyocyteexcitabilitywithimplicationsforarrhythmiageneration AT jingweimeng cardiacsodiumchannelpalmitoylationregulateschannelavailabilityandmyocyteexcitabilitywithimplicationsforarrhythmiageneration AT andyhudmon cardiacsodiumchannelpalmitoylationregulateschannelavailabilityandmyocyteexcitabilitywithimplicationsforarrhythmiageneration AT theodorercummins cardiacsodiumchannelpalmitoylationregulateschannelavailabilityandmyocyteexcitabilitywithimplicationsforarrhythmiageneration
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Cardiac sodium channel palmitoylation regulates channel availability and myocyte excitability with implications for arrhythmia generation

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