Modeling Dominant and Recessive Forms of Retinitis Pigmentosa by Editing Three Rhodopsin-Encoding Genes in Xenopus Laevis Using Crispr/Cas9

Modeling Dominant and Recessive Forms of Retinitis Pigmentosa by Editing Three Rhodopsin-Encoding Genes in Xenopus Laevis Using Crispr/Cas9

Abstract The utility of Xenopus laevis, a common research subject for developmental biology, retinal physiology, cell biology, and other investigations, has been limited by lack of a robust gene knockout or knock-down technology. Here we describe manipulation of the X. laevis genome using CRISPR/Cas...

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Autores principales: Joanna M. Feehan, Colette N. Chiu, Paloma Stanar, Beatrice M. Tam, Sheikh N. Ahmed, Orson L. Moritz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Medicine
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Science
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Acceso en línea:https://doaj.org/article/ab62bec43fb74a4b8129521e5badc389
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