Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors

Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors

Down syndrome (DS) is caused by trisomy 21 (T21), but the underlying etiology of the related immune and neurological dysfunction is unclear. Here, the authors show that T21 activates the kynurenine pathway via increased interferon receptor copy number, which could contribute to DS pathophysiology.

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Autores principales: Rani K. Powers, Rachel Culp-Hill, Michael P. Ludwig, Keith P. Smith, Katherine A. Waugh, Ross Minter, Kathryn D. Tuttle, Hannah C. Lewis, Angela L. Rachubinski, Ross E. Granrath, María Carmona-Iragui, Rebecca B. Wilkerson, Darcy E. Kahn, Molishree Joshi, Alberto Lleó, Rafael Blesa, Juan Fortea, Angelo D’Alessandro, James C. Costello, Kelly D. Sullivan, Joaquin M. Espinosa
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/ab62f68b2f204b5a960385c4c5866d85
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spelling oai:doaj.org-article:ab62f68b2f204b5a960385c4c5866d852021-12-02T15:35:16ZTrisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors10.1038/s41467-019-12739-92041-1723https://doaj.org/article/ab62f68b2f204b5a960385c4c5866d852019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12739-9https://doaj.org/toc/2041-1723Down syndrome (DS) is caused by trisomy 21 (T21), but the underlying etiology of the related immune and neurological dysfunction is unclear. Here, the authors show that T21 activates the kynurenine pathway via increased interferon receptor copy number, which could contribute to DS pathophysiology.Rani K. PowersRachel Culp-HillMichael P. LudwigKeith P. SmithKatherine A. WaughRoss MinterKathryn D. TuttleHannah C. LewisAngela L. RachubinskiRoss E. GranrathMaría Carmona-IraguiRebecca B. WilkersonDarcy E. KahnMolishree JoshiAlberto LleóRafael BlesaJuan ForteaAngelo D’AlessandroJames C. CostelloKelly D. SullivanJoaquin M. EspinosaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Rani K. Powers
Rachel Culp-Hill
Michael P. Ludwig
Keith P. Smith
Katherine A. Waugh
Ross Minter
Kathryn D. Tuttle
Hannah C. Lewis
Angela L. Rachubinski
Ross E. Granrath
María Carmona-Iragui
Rebecca B. Wilkerson
Darcy E. Kahn
Molishree Joshi
Alberto Lleó
Rafael Blesa
Juan Fortea
Angelo D’Alessandro
James C. Costello
Kelly D. Sullivan
Joaquin M. Espinosa
Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors
description Down syndrome (DS) is caused by trisomy 21 (T21), but the underlying etiology of the related immune and neurological dysfunction is unclear. Here, the authors show that T21 activates the kynurenine pathway via increased interferon receptor copy number, which could contribute to DS pathophysiology.
format article
author Rani K. Powers
Rachel Culp-Hill
Michael P. Ludwig
Keith P. Smith
Katherine A. Waugh
Ross Minter
Kathryn D. Tuttle
Hannah C. Lewis
Angela L. Rachubinski
Ross E. Granrath
María Carmona-Iragui
Rebecca B. Wilkerson
Darcy E. Kahn
Molishree Joshi
Alberto Lleó
Rafael Blesa
Juan Fortea
Angelo D’Alessandro
James C. Costello
Kelly D. Sullivan
Joaquin M. Espinosa
author_facet Rani K. Powers
Rachel Culp-Hill
Michael P. Ludwig
Keith P. Smith
Katherine A. Waugh
Ross Minter
Kathryn D. Tuttle
Hannah C. Lewis
Angela L. Rachubinski
Ross E. Granrath
María Carmona-Iragui
Rebecca B. Wilkerson
Darcy E. Kahn
Molishree Joshi
Alberto Lleó
Rafael Blesa
Juan Fortea
Angelo D’Alessandro
James C. Costello
Kelly D. Sullivan
Joaquin M. Espinosa
author_sort Rani K. Powers
title Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors
title_short Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors
title_full Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors
title_fullStr Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors
title_full_unstemmed Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors
title_sort trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/ab62f68b2f204b5a960385c4c5866d85
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