Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid

Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid

Non-proteinogenic (np) amino acids in the food chain present challenges for the human translation machinery. Here the authors show that, while AlaRS and ProRS activate toxic np azetidine-2-carboxylic acid (Aze) present in sugar beets and lilies, only the AlaRS editing system rejects Aze.

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Detalles Bibliográficos
Autores principales: Youngzee Song, Huihao Zhou, My-Nuong Vo, Yi Shi, Mir Hussain Nawaz, Oscar Vargas-Rodriguez, Jolene K. Diedrich, John R. Yates, Shuji Kishi, Karin Musier-Forsyth, Paul Schimmel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/ab6942f80cab4c61b84fff08d09c316d
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Descripción
Sumario:Non-proteinogenic (np) amino acids in the food chain present challenges for the human translation machinery. Here the authors show that, while AlaRS and ProRS activate toxic np azetidine-2-carboxylic acid (Aze) present in sugar beets and lilies, only the AlaRS editing system rejects Aze.

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