Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid

Non-proteinogenic (np) amino acids in the food chain present challenges for the human translation machinery. Here the authors show that, while AlaRS and ProRS activate toxic np azetidine-2-carboxylic acid (Aze) present in sugar beets and lilies, only the AlaRS editing system rejects Aze.

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Autores principales:	Youngzee Song, Huihao Zhou, My-Nuong Vo, Yi Shi, Mir Hussain Nawaz, Oscar Vargas-Rodriguez, Jolene K. Diedrich, John R. Yates, Shuji Kishi, Karin Musier-Forsyth, Paul Schimmel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ab6942f80cab4c61b84fff08d09c316d
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spelling	oai:doaj.org-article:ab6942f80cab4c61b84fff08d09c316d2021-12-02T13:24:23ZDouble mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid10.1038/s41467-017-02201-z2041-1723https://doaj.org/article/ab6942f80cab4c61b84fff08d09c316d2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02201-zhttps://doaj.org/toc/2041-1723Non-proteinogenic (np) amino acids in the food chain present challenges for the human translation machinery. Here the authors show that, while AlaRS and ProRS activate toxic np azetidine-2-carboxylic acid (Aze) present in sugar beets and lilies, only the AlaRS editing system rejects Aze.Youngzee SongHuihao ZhouMy-Nuong VoYi ShiMir Hussain NawazOscar Vargas-RodriguezJolene K. DiedrichJohn R. YatesShuji KishiKarin Musier-ForsythPaul SchimmelNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Youngzee Song Huihao Zhou My-Nuong Vo Yi Shi Mir Hussain Nawaz Oscar Vargas-Rodriguez Jolene K. Diedrich John R. Yates Shuji Kishi Karin Musier-Forsyth Paul Schimmel Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid
description	Non-proteinogenic (np) amino acids in the food chain present challenges for the human translation machinery. Here the authors show that, while AlaRS and ProRS activate toxic np azetidine-2-carboxylic acid (Aze) present in sugar beets and lilies, only the AlaRS editing system rejects Aze.
format	article
author	Youngzee Song Huihao Zhou My-Nuong Vo Yi Shi Mir Hussain Nawaz Oscar Vargas-Rodriguez Jolene K. Diedrich John R. Yates Shuji Kishi Karin Musier-Forsyth Paul Schimmel
author_facet	Youngzee Song Huihao Zhou My-Nuong Vo Yi Shi Mir Hussain Nawaz Oscar Vargas-Rodriguez Jolene K. Diedrich John R. Yates Shuji Kishi Karin Musier-Forsyth Paul Schimmel
author_sort	Youngzee Song
title	Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid
title_short	Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid
title_full	Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid
title_fullStr	Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid
title_full_unstemmed	Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid
title_sort	double mimicry evades trna synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ab6942f80cab4c61b84fff08d09c316d
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Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid

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