Artificial Cornea: Past, Current, and Future Directions

Corneal diseases are a leading cause of blindness with an estimated 10 million patients diagnosed with bilateral corneal blindness worldwide. Corneal transplantation is highly successful in low-risk patients with corneal blindness but often fails those with high-risk indications such as recurrent or...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gráinne Holland, Abhay Pandit, Laura Sánchez-Abella, Andrea Haiek, Iraida Loinaz, Damien Dupin, Maria Gonzalez, Eva Larra, Aritz Bidaguren, Neil Lagali, Elizabeth B. Moloney, Thomas Ritter
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	artificial cornea blindness biointegration Boston type-1 keratoprostheses osteo-odonto-keratoprostheses AlphaCor™ Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ab6b6cfd474f43dbb78dc606d4542794
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ab6b6cfd474f43dbb78dc606d4542794
record_format	dspace
spelling	oai:doaj.org-article:ab6b6cfd474f43dbb78dc606d45427942021-11-12T05:19:27ZArtificial Cornea: Past, Current, and Future Directions2296-858X10.3389/fmed.2021.770780https://doaj.org/article/ab6b6cfd474f43dbb78dc606d45427942021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.770780/fullhttps://doaj.org/toc/2296-858XCorneal diseases are a leading cause of blindness with an estimated 10 million patients diagnosed with bilateral corneal blindness worldwide. Corneal transplantation is highly successful in low-risk patients with corneal blindness but often fails those with high-risk indications such as recurrent or chronic inflammatory disorders, history of glaucoma and herpetic infections, and those with neovascularisation of the host bed. Moreover, the need for donor corneas greatly exceeds the supply, especially in disadvantaged countries. Therefore, artificial and bio-mimetic corneas have been investigated for patients with indications that result in keratoplasty failure. Two long-lasting keratoprostheses with different indications, the Boston type-1 keratoprostheses and osteo-odonto-keratoprostheses have been adapted to minimise complications that have arisen over time. However, both utilise either autologous tissue or an allograft cornea to increase biointegration. To step away from the need for donor material, synthetic keratoprostheses with soft skirts have been introduced to increase biointegration between the device and native tissue. The AlphaCor™, a synthetic polymer (PHEMA) hydrogel, addressed certain complications of the previous versions of keratoprostheses but resulted in stromal melting and optic deposition. Efforts are being made towards creating synthetic keratoprostheses that emulate native corneas by the inclusion of biomolecules that support enhanced biointegration of the implant while reducing stromal melting and optic deposition. The field continues to shift towards more advanced bioengineering approaches to form replacement corneas. Certain biomolecules such as collagen are being investigated to create corneal substitutes, which can be used as the basis for bio-inks in 3D corneal bioprinting. Alternatively, decellularised corneas from mammalian sources have shown potential in replicating both the corneal composition and fibril architecture. This review will discuss the limitations of keratoplasty, milestones in the history of artificial corneal development, advancements in current artificial corneas, and future possibilities in this field.Gráinne HollandAbhay PanditLaura Sánchez-AbellaAndrea HaiekIraida LoinazDamien DupinMaria GonzalezEva LarraAritz BidagurenNeil LagaliElizabeth B. MoloneyElizabeth B. MoloneyThomas RitterThomas RitterFrontiers Media S.A.articleartificial corneablindnessbiointegrationBoston type-1 keratoprosthesesosteo-odonto-keratoprosthesesAlphaCor™Medicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	artificial cornea blindness biointegration Boston type-1 keratoprostheses osteo-odonto-keratoprostheses AlphaCor™ Medicine (General) R5-920
spellingShingle	artificial cornea blindness biointegration Boston type-1 keratoprostheses osteo-odonto-keratoprostheses AlphaCor™ Medicine (General) R5-920 Gráinne Holland Abhay Pandit Laura Sánchez-Abella Andrea Haiek Iraida Loinaz Damien Dupin Maria Gonzalez Eva Larra Aritz Bidaguren Neil Lagali Elizabeth B. Moloney Elizabeth B. Moloney Thomas Ritter Thomas Ritter Artificial Cornea: Past, Current, and Future Directions
description	Corneal diseases are a leading cause of blindness with an estimated 10 million patients diagnosed with bilateral corneal blindness worldwide. Corneal transplantation is highly successful in low-risk patients with corneal blindness but often fails those with high-risk indications such as recurrent or chronic inflammatory disorders, history of glaucoma and herpetic infections, and those with neovascularisation of the host bed. Moreover, the need for donor corneas greatly exceeds the supply, especially in disadvantaged countries. Therefore, artificial and bio-mimetic corneas have been investigated for patients with indications that result in keratoplasty failure. Two long-lasting keratoprostheses with different indications, the Boston type-1 keratoprostheses and osteo-odonto-keratoprostheses have been adapted to minimise complications that have arisen over time. However, both utilise either autologous tissue or an allograft cornea to increase biointegration. To step away from the need for donor material, synthetic keratoprostheses with soft skirts have been introduced to increase biointegration between the device and native tissue. The AlphaCor™, a synthetic polymer (PHEMA) hydrogel, addressed certain complications of the previous versions of keratoprostheses but resulted in stromal melting and optic deposition. Efforts are being made towards creating synthetic keratoprostheses that emulate native corneas by the inclusion of biomolecules that support enhanced biointegration of the implant while reducing stromal melting and optic deposition. The field continues to shift towards more advanced bioengineering approaches to form replacement corneas. Certain biomolecules such as collagen are being investigated to create corneal substitutes, which can be used as the basis for bio-inks in 3D corneal bioprinting. Alternatively, decellularised corneas from mammalian sources have shown potential in replicating both the corneal composition and fibril architecture. This review will discuss the limitations of keratoplasty, milestones in the history of artificial corneal development, advancements in current artificial corneas, and future possibilities in this field.
format	article
author	Gráinne Holland Abhay Pandit Laura Sánchez-Abella Andrea Haiek Iraida Loinaz Damien Dupin Maria Gonzalez Eva Larra Aritz Bidaguren Neil Lagali Elizabeth B. Moloney Elizabeth B. Moloney Thomas Ritter Thomas Ritter
author_facet	Gráinne Holland Abhay Pandit Laura Sánchez-Abella Andrea Haiek Iraida Loinaz Damien Dupin Maria Gonzalez Eva Larra Aritz Bidaguren Neil Lagali Elizabeth B. Moloney Elizabeth B. Moloney Thomas Ritter Thomas Ritter
author_sort	Gráinne Holland
title	Artificial Cornea: Past, Current, and Future Directions
title_short	Artificial Cornea: Past, Current, and Future Directions
title_full	Artificial Cornea: Past, Current, and Future Directions
title_fullStr	Artificial Cornea: Past, Current, and Future Directions
title_full_unstemmed	Artificial Cornea: Past, Current, and Future Directions
title_sort	artificial cornea: past, current, and future directions
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ab6b6cfd474f43dbb78dc606d4542794
work_keys_str_mv	AT grainneholland artificialcorneapastcurrentandfuturedirections AT abhaypandit artificialcorneapastcurrentandfuturedirections AT laurasanchezabella artificialcorneapastcurrentandfuturedirections AT andreahaiek artificialcorneapastcurrentandfuturedirections AT iraidaloinaz artificialcorneapastcurrentandfuturedirections AT damiendupin artificialcorneapastcurrentandfuturedirections AT mariagonzalez artificialcorneapastcurrentandfuturedirections AT evalarra artificialcorneapastcurrentandfuturedirections AT aritzbidaguren artificialcorneapastcurrentandfuturedirections AT neillagali artificialcorneapastcurrentandfuturedirections AT elizabethbmoloney artificialcorneapastcurrentandfuturedirections AT elizabethbmoloney artificialcorneapastcurrentandfuturedirections AT thomasritter artificialcorneapastcurrentandfuturedirections AT thomasritter artificialcorneapastcurrentandfuturedirections
_version_	1718431190778642432

Artificial Cornea: Past, Current, and Future Directions

Ejemplares similares