Oscillating field stimulation promotes axon regeneration and locomotor recovery after spinal cord injury
Oscillating field stimulation (OFS) is a potential method for treating spinal cord injury. Although it has been used in spinal cord injury (SCI) therapy in basic and clinical studies, its underlying mechanism and the correlation between its duration and nerve injury repair remain poorly understood....
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Wolters Kluwer Medknow Publications
2022
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oai:doaj.org-article:ab6b7b8d04c1417481e3d0854e67e3412021-11-19T12:16:44ZOscillating field stimulation promotes axon regeneration and locomotor recovery after spinal cord injury1673-537410.4103/1673-5374.327349https://doaj.org/article/ab6b7b8d04c1417481e3d0854e67e3412022-01-01T00:00:00Zhttp://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=6;spage=1318;epage=1323;aulast=Wanghttps://doaj.org/toc/1673-5374Oscillating field stimulation (OFS) is a potential method for treating spinal cord injury. Although it has been used in spinal cord injury (SCI) therapy in basic and clinical studies, its underlying mechanism and the correlation between its duration and nerve injury repair remain poorly understood. In this study, we established rat models of spinal cord contusion at T10 and then administered 12 weeks of OFS. The results revealed that effectively promotes the recovery of motor function required continuous OFS for more than 6 weeks. The underlying mechanism may be related to the effects of OFS on promoting axon regeneration, inhibiting astrocyte proliferation, and improving the linear arrangement of astrocytes. This study was approved by the Animal Experiments and Experimental Animal Welfare Committee of Capital Medical University (supplemental approval No. AEEI-2021-204) on July 26, 2021.Yi-Xin WangJin-Zhu BaiZhen LyuGuang-Hao ZhangXiao-Lin HuoWolters Kluwer Medknow Publicationsarticleastrocyte orientation; astrocyte proliferation; axonal regeneration; locomotor recovery; neural regeneration; neural repair; oscillating field stimulation; spinal cord injury; stimulus durationNeurology. Diseases of the nervous systemRC346-429ENNeural Regeneration Research, Vol 17, Iss 6, Pp 1318-1323 (2022) |
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DOAJ |
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DOAJ |
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EN |
| topic |
astrocyte orientation; astrocyte proliferation; axonal regeneration; locomotor recovery; neural regeneration; neural repair; oscillating field stimulation; spinal cord injury; stimulus duration Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
astrocyte orientation; astrocyte proliferation; axonal regeneration; locomotor recovery; neural regeneration; neural repair; oscillating field stimulation; spinal cord injury; stimulus duration Neurology. Diseases of the nervous system RC346-429 Yi-Xin Wang Jin-Zhu Bai Zhen Lyu Guang-Hao Zhang Xiao-Lin Huo Oscillating field stimulation promotes axon regeneration and locomotor recovery after spinal cord injury |
| description |
Oscillating field stimulation (OFS) is a potential method for treating spinal cord injury. Although it has been used in spinal cord injury (SCI) therapy in basic and clinical studies, its underlying mechanism and the correlation between its duration and nerve injury repair remain poorly understood. In this study, we established rat models of spinal cord contusion at T10 and then administered 12 weeks of OFS. The results revealed that effectively promotes the recovery of motor function required continuous OFS for more than 6 weeks. The underlying mechanism may be related to the effects of OFS on promoting axon regeneration, inhibiting astrocyte proliferation, and improving the linear arrangement of astrocytes. This study was approved by the Animal Experiments and Experimental Animal Welfare Committee of Capital Medical University (supplemental approval No. AEEI-2021-204) on July 26, 2021. |
| format |
article |
| author |
Yi-Xin Wang Jin-Zhu Bai Zhen Lyu Guang-Hao Zhang Xiao-Lin Huo |
| author_facet |
Yi-Xin Wang Jin-Zhu Bai Zhen Lyu Guang-Hao Zhang Xiao-Lin Huo |
| author_sort |
Yi-Xin Wang |
| title |
Oscillating field stimulation promotes axon regeneration and locomotor recovery after spinal cord injury |
| title_short |
Oscillating field stimulation promotes axon regeneration and locomotor recovery after spinal cord injury |
| title_full |
Oscillating field stimulation promotes axon regeneration and locomotor recovery after spinal cord injury |
| title_fullStr |
Oscillating field stimulation promotes axon regeneration and locomotor recovery after spinal cord injury |
| title_full_unstemmed |
Oscillating field stimulation promotes axon regeneration and locomotor recovery after spinal cord injury |
| title_sort |
oscillating field stimulation promotes axon regeneration and locomotor recovery after spinal cord injury |
| publisher |
Wolters Kluwer Medknow Publications |
| publishDate |
2022 |
| url |
https://doaj.org/article/ab6b7b8d04c1417481e3d0854e67e341 |
| work_keys_str_mv |
AT yixinwang oscillatingfieldstimulationpromotesaxonregenerationandlocomotorrecoveryafterspinalcordinjury AT jinzhubai oscillatingfieldstimulationpromotesaxonregenerationandlocomotorrecoveryafterspinalcordinjury AT zhenlyu oscillatingfieldstimulationpromotesaxonregenerationandlocomotorrecoveryafterspinalcordinjury AT guanghaozhang oscillatingfieldstimulationpromotesaxonregenerationandlocomotorrecoveryafterspinalcordinjury AT xiaolinhuo oscillatingfieldstimulationpromotesaxonregenerationandlocomotorrecoveryafterspinalcordinjury |
| _version_ |
1718420089365069824 |