Telomere attrition rates are associated with weather conditions and predict productive lifespan in dairy cattle

Abstract Telomere length is predictive of adult health and survival across vertebrate species. However, we currently do not know whether such associations result from among-individual differences in telomere length determined genetically or by early-life environmental conditions, or from differences...

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Autores principales:	Luise A. Seeker, Sarah L. Underwood, Rachael V. Wilbourn, Jennifer Dorrens, Hannah Froy, Rebecca Holland, Joanna J. Ilska, Androniki Psifidi, Ainsley Bagnall, Bruce Whitelaw, Mike Coffey, Georgios Banos, Daniel H. Nussey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ab6c6709e3b64eb4a9068e831fb649dc
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spelling	oai:doaj.org-article:ab6c6709e3b64eb4a9068e831fb649dc2021-12-02T13:34:33ZTelomere attrition rates are associated with weather conditions and predict productive lifespan in dairy cattle10.1038/s41598-021-84984-22045-2322https://doaj.org/article/ab6c6709e3b64eb4a9068e831fb649dc2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84984-2https://doaj.org/toc/2045-2322Abstract Telomere length is predictive of adult health and survival across vertebrate species. However, we currently do not know whether such associations result from among-individual differences in telomere length determined genetically or by early-life environmental conditions, or from differences in the rate of telomere attrition over the course of life that might be affected by environmental conditions. Here, we measured relative leukocyte telomere length (RLTL) multiple times across the entire lifespan of dairy cattle in a research population that is closely monitored for health and milk production and where individuals are predominantly culled in response to health issues. Animals varied in their change in RLTL between subsequent measurements and RLTL shortened more during early life and following hotter summers which are known to cause heat stress in dairy cows. The average amount of telomere attrition calculated over multiple repeat samples of individuals predicted a shorter productive lifespan, suggesting a link between telomere loss and health. TL attrition was a better predictor of when an animal was culled than their average TL or the previously for this population reported significant TL at the age of 1 year. Our present results support the hypothesis that TL is a flexible trait that is affected by environmental factors and that telomere attrition is linked to animal health and survival traits. Change in telomere length may represent a useful biomarker in animal welfare studies.Luise A. SeekerSarah L. UnderwoodRachael V. WilbournJennifer DorrensHannah FroyRebecca HollandJoanna J. IlskaAndroniki PsifidiAinsley BagnallBruce WhitelawMike CoffeyGeorgios BanosDaniel H. NusseyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Luise A. Seeker Sarah L. Underwood Rachael V. Wilbourn Jennifer Dorrens Hannah Froy Rebecca Holland Joanna J. Ilska Androniki Psifidi Ainsley Bagnall Bruce Whitelaw Mike Coffey Georgios Banos Daniel H. Nussey Telomere attrition rates are associated with weather conditions and predict productive lifespan in dairy cattle
description	Abstract Telomere length is predictive of adult health and survival across vertebrate species. However, we currently do not know whether such associations result from among-individual differences in telomere length determined genetically or by early-life environmental conditions, or from differences in the rate of telomere attrition over the course of life that might be affected by environmental conditions. Here, we measured relative leukocyte telomere length (RLTL) multiple times across the entire lifespan of dairy cattle in a research population that is closely monitored for health and milk production and where individuals are predominantly culled in response to health issues. Animals varied in their change in RLTL between subsequent measurements and RLTL shortened more during early life and following hotter summers which are known to cause heat stress in dairy cows. The average amount of telomere attrition calculated over multiple repeat samples of individuals predicted a shorter productive lifespan, suggesting a link between telomere loss and health. TL attrition was a better predictor of when an animal was culled than their average TL or the previously for this population reported significant TL at the age of 1 year. Our present results support the hypothesis that TL is a flexible trait that is affected by environmental factors and that telomere attrition is linked to animal health and survival traits. Change in telomere length may represent a useful biomarker in animal welfare studies.
format	article
author	Luise A. Seeker Sarah L. Underwood Rachael V. Wilbourn Jennifer Dorrens Hannah Froy Rebecca Holland Joanna J. Ilska Androniki Psifidi Ainsley Bagnall Bruce Whitelaw Mike Coffey Georgios Banos Daniel H. Nussey
author_facet	Luise A. Seeker Sarah L. Underwood Rachael V. Wilbourn Jennifer Dorrens Hannah Froy Rebecca Holland Joanna J. Ilska Androniki Psifidi Ainsley Bagnall Bruce Whitelaw Mike Coffey Georgios Banos Daniel H. Nussey
author_sort	Luise A. Seeker
title	Telomere attrition rates are associated with weather conditions and predict productive lifespan in dairy cattle
title_short	Telomere attrition rates are associated with weather conditions and predict productive lifespan in dairy cattle
title_full	Telomere attrition rates are associated with weather conditions and predict productive lifespan in dairy cattle
title_fullStr	Telomere attrition rates are associated with weather conditions and predict productive lifespan in dairy cattle
title_full_unstemmed	Telomere attrition rates are associated with weather conditions and predict productive lifespan in dairy cattle
title_sort	telomere attrition rates are associated with weather conditions and predict productive lifespan in dairy cattle
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ab6c6709e3b64eb4a9068e831fb649dc
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Telomere attrition rates are associated with weather conditions and predict productive lifespan in dairy cattle

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