Optimal authoritative risk assessment score of Cancer-associated venous thromboembolism for hospitalized medical patients with lung Cancer

Abstract Background Cancer-associated venous thromboembolism (VTE) is common in patients with primary lung cancer. It has been understudied which authoritative risk assessment score of cancer-associated VTE is optimal for the assessment of VTE development in hospitalized medical patients with lung c...

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Autores principales:	Wei Xiong, Yunfeng Zhao, He Du, Yanmin Wang, Mei Xu, Xuejun Guo
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Lung cancer Venous thromboembolism Cancer-associated VTE Risk assessment score Hospitalized medical patients Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/ab6ea2e1d80e4cbca5164d3c0a92ce5c
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spelling	oai:doaj.org-article:ab6ea2e1d80e4cbca5164d3c0a92ce5c2021-12-05T12:18:42ZOptimal authoritative risk assessment score of Cancer-associated venous thromboembolism for hospitalized medical patients with lung Cancer10.1186/s12959-021-00339-x1477-9560https://doaj.org/article/ab6ea2e1d80e4cbca5164d3c0a92ce5c2021-12-01T00:00:00Zhttps://doi.org/10.1186/s12959-021-00339-xhttps://doaj.org/toc/1477-9560Abstract Background Cancer-associated venous thromboembolism (VTE) is common in patients with primary lung cancer. It has been understudied which authoritative risk assessment score of cancer-associated VTE is optimal for the assessment of VTE development in hospitalized medical patients with lung cancer. Methods Patients with lung cancer who had undergone computed tomography pulmonary angiography (CTPA), compression ultrasonography (CUS) of lower and upper extremities, and/or planar ventilation/perfusion (V/Q) scan to confirm the presence or absence of VTE during a medical hospitalization were retrospectively reviewed. Based on the actual prevalence of VTE among all patients, the possibility of VTE were reassessed with the Khorana score, the PROTECHT score, the CONKO score, the ONKOTEV score, the COMPASS-CAT score, and the CATS/MICA score, to compare their assessment accuracy for VTE development. Results A total of 1263 patients with lung cancer were incorporated into the final analysis. With respect to assessment efficiency for VTE occurrence, the scores with adjusted agreement from highest to lowest were the ONKOTEV score (78.6%), the PROTECHT score (73.4%), the CONKO score (72.1%), the COMPASS-CAT score (71.7%), the Khorana score (70.9%), and the CATS/MICA score (60.3%). The ONKOTEV score had the highest Youden index which was 0.68, followed by the PROTECHT score (0.58), the COMPASS-CAT score (0.56), the CONKO score (0.55), the Khorana score (0.53), and the CATS/MICA score (0.23). Conclusions Among the Khorana score, the PROTECHT score, the CONKO score, the ONKOTEV score, the COMPASS-CAT score, and the CATS/MICA score which are approved by authoritative guidelines, the ONKOTEV score is optimal for the assessment of VTE development in hospitalized medical patients with lung cancer.Wei XiongYunfeng ZhaoHe DuYanmin WangMei XuXuejun GuoBMCarticleLung cancerVenous thromboembolismCancer-associated VTERisk assessment scoreHospitalized medical patientsDiseases of the blood and blood-forming organsRC633-647.5ENThrombosis Journal, Vol 19, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lung cancer Venous thromboembolism Cancer-associated VTE Risk assessment score Hospitalized medical patients Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Lung cancer Venous thromboembolism Cancer-associated VTE Risk assessment score Hospitalized medical patients Diseases of the blood and blood-forming organs RC633-647.5 Wei Xiong Yunfeng Zhao He Du Yanmin Wang Mei Xu Xuejun Guo Optimal authoritative risk assessment score of Cancer-associated venous thromboembolism for hospitalized medical patients with lung Cancer
description	Abstract Background Cancer-associated venous thromboembolism (VTE) is common in patients with primary lung cancer. It has been understudied which authoritative risk assessment score of cancer-associated VTE is optimal for the assessment of VTE development in hospitalized medical patients with lung cancer. Methods Patients with lung cancer who had undergone computed tomography pulmonary angiography (CTPA), compression ultrasonography (CUS) of lower and upper extremities, and/or planar ventilation/perfusion (V/Q) scan to confirm the presence or absence of VTE during a medical hospitalization were retrospectively reviewed. Based on the actual prevalence of VTE among all patients, the possibility of VTE were reassessed with the Khorana score, the PROTECHT score, the CONKO score, the ONKOTEV score, the COMPASS-CAT score, and the CATS/MICA score, to compare their assessment accuracy for VTE development. Results A total of 1263 patients with lung cancer were incorporated into the final analysis. With respect to assessment efficiency for VTE occurrence, the scores with adjusted agreement from highest to lowest were the ONKOTEV score (78.6%), the PROTECHT score (73.4%), the CONKO score (72.1%), the COMPASS-CAT score (71.7%), the Khorana score (70.9%), and the CATS/MICA score (60.3%). The ONKOTEV score had the highest Youden index which was 0.68, followed by the PROTECHT score (0.58), the COMPASS-CAT score (0.56), the CONKO score (0.55), the Khorana score (0.53), and the CATS/MICA score (0.23). Conclusions Among the Khorana score, the PROTECHT score, the CONKO score, the ONKOTEV score, the COMPASS-CAT score, and the CATS/MICA score which are approved by authoritative guidelines, the ONKOTEV score is optimal for the assessment of VTE development in hospitalized medical patients with lung cancer.
format	article
author	Wei Xiong Yunfeng Zhao He Du Yanmin Wang Mei Xu Xuejun Guo
author_facet	Wei Xiong Yunfeng Zhao He Du Yanmin Wang Mei Xu Xuejun Guo
author_sort	Wei Xiong
title	Optimal authoritative risk assessment score of Cancer-associated venous thromboembolism for hospitalized medical patients with lung Cancer
title_short	Optimal authoritative risk assessment score of Cancer-associated venous thromboembolism for hospitalized medical patients with lung Cancer
title_full	Optimal authoritative risk assessment score of Cancer-associated venous thromboembolism for hospitalized medical patients with lung Cancer
title_fullStr	Optimal authoritative risk assessment score of Cancer-associated venous thromboembolism for hospitalized medical patients with lung Cancer
title_full_unstemmed	Optimal authoritative risk assessment score of Cancer-associated venous thromboembolism for hospitalized medical patients with lung Cancer
title_sort	optimal authoritative risk assessment score of cancer-associated venous thromboembolism for hospitalized medical patients with lung cancer
publisher	BMC
publishDate	2021
url	https://doaj.org/article/ab6ea2e1d80e4cbca5164d3c0a92ce5c
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Optimal authoritative risk assessment score of Cancer-associated venous thromboembolism for hospitalized medical patients with lung Cancer

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