Mapping the conformational dynamics and pathways of spontaneous steric zipper Peptide oligomerization.

The process of protein misfolding and self-assembly into various, polymorphic aggregates is associated with a number of important neurodegenerative diseases. Only recently, crystal structures of several short peptides have provided detailed structural insights into -sheet rich aggregates, known as a...

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Auteurs principaux: Dirk Matthes, Vytautas Gapsys, Venita Daebel, Bert L de Groot
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2011
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R
Q
Accès en ligne:https://doaj.org/article/ab6fbce3cc9f4e6ca56fd3e71980b6c0
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