Croton cajucara Essential Oil Nanoemulsion and Its Antifungal Activities

The purpose of this study was to develop a stable nanoemulsion (NE) containing Croton cajucara 7-hydroxycalamenene-rich essential oil (NECC) with antifungal activity. The NECCs were prepared using an ultrasonic processor with Pluronic® F-127 as the aqueous p...

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Autores principales:	Mariana M. B. Azevedo, Catia A. Almeida, Francisco C. M. Chaves, Eduardo Ricci-Júnior, Andreza R. Garcia, Igor A. Rodrigues, Celuta S. Alviano, Daniela S. Alviano
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	nanoemulsion <i>Croton cajucara</i> essential oil antifungal activity Chemical technology TP1-1185 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/ab71a00481444b37a9ea0927df373040
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id	oai:doaj.org-article:ab71a00481444b37a9ea0927df373040
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spelling	oai:doaj.org-article:ab71a00481444b37a9ea0927df3730402021-11-25T18:49:57Z<i>Croton cajucara</i> Essential Oil Nanoemulsion and Its Antifungal Activities10.3390/pr91118722227-9717https://doaj.org/article/ab71a00481444b37a9ea0927df3730402021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9717/9/11/1872https://doaj.org/toc/2227-9717The purpose of this study was to develop a stable nanoemulsion (NE) containing <i>Croton cajucara</i> 7-hydroxycalamenene-rich essential oil (NECC) with antifungal activity. The NECCs were prepared using an ultrasonic processor with Pluronic<sup>®</sup> F-127 as the aqueous phase. In order to evaluate the NECCs, the droplet size, polydispersity index (PdI), percentage of emulsification, and pH were determined along with a stability study. The NECC selected for the study had 15% surfactant, showed 100% emulsification, Pdl of 0.249, neutral pH, droplet diameters of about 40 nm, and remained stable over 150 days at room temperature. In addition, the NECC activity against some species of Zygomycetes and Candida, as well as the potential to inhibit fungal extracellular proteases, were assessed, and, finally, the hemolytic activity was evaluated. The best NECC antifungal activities were against <i>Mucor</i><i>ramosissimus</i> (Minimal inhibitory concentration (MIC) = 12.2 μg/mL) and <i>Candida albicans</i> (MIC = 25.6 μg/mL). The highest extracellular protease activities of <i>M. ramosissimus</i> and <i>C. albicans</i> were detected at pH 3 and 4, respectively, which were totally inhibited after NECC treatment. The NECC showed no hemolytic effect at the highest concentration tested (2 mg/mL).Mariana M. B. AzevedoCatia A. AlmeidaFrancisco C. M. ChavesEduardo Ricci-JúniorAndreza R. GarciaIgor A. RodriguesCeluta S. AlvianoDaniela S. AlvianoMDPI AGarticlenanoemulsion<i>Croton cajucara</i>essential oilantifungal activityChemical technologyTP1-1185ChemistryQD1-999ENProcesses, Vol 9, Iss 1872, p 1872 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanoemulsion <i>Croton cajucara</i> essential oil antifungal activity Chemical technology TP1-1185 Chemistry QD1-999
spellingShingle	nanoemulsion <i>Croton cajucara</i> essential oil antifungal activity Chemical technology TP1-1185 Chemistry QD1-999 Mariana M. B. Azevedo Catia A. Almeida Francisco C. M. Chaves Eduardo Ricci-Júnior Andreza R. Garcia Igor A. Rodrigues Celuta S. Alviano Daniela S. Alviano <i>Croton cajucara</i> Essential Oil Nanoemulsion and Its Antifungal Activities
description	The purpose of this study was to develop a stable nanoemulsion (NE) containing <i>Croton cajucara</i> 7-hydroxycalamenene-rich essential oil (NECC) with antifungal activity. The NECCs were prepared using an ultrasonic processor with Pluronic<sup>®</sup> F-127 as the aqueous phase. In order to evaluate the NECCs, the droplet size, polydispersity index (PdI), percentage of emulsification, and pH were determined along with a stability study. The NECC selected for the study had 15% surfactant, showed 100% emulsification, Pdl of 0.249, neutral pH, droplet diameters of about 40 nm, and remained stable over 150 days at room temperature. In addition, the NECC activity against some species of Zygomycetes and Candida, as well as the potential to inhibit fungal extracellular proteases, were assessed, and, finally, the hemolytic activity was evaluated. The best NECC antifungal activities were against <i>Mucor</i><i>ramosissimus</i> (Minimal inhibitory concentration (MIC) = 12.2 μg/mL) and <i>Candida albicans</i> (MIC = 25.6 μg/mL). The highest extracellular protease activities of <i>M. ramosissimus</i> and <i>C. albicans</i> were detected at pH 3 and 4, respectively, which were totally inhibited after NECC treatment. The NECC showed no hemolytic effect at the highest concentration tested (2 mg/mL).
format	article
author	Mariana M. B. Azevedo Catia A. Almeida Francisco C. M. Chaves Eduardo Ricci-Júnior Andreza R. Garcia Igor A. Rodrigues Celuta S. Alviano Daniela S. Alviano
author_facet	Mariana M. B. Azevedo Catia A. Almeida Francisco C. M. Chaves Eduardo Ricci-Júnior Andreza R. Garcia Igor A. Rodrigues Celuta S. Alviano Daniela S. Alviano
author_sort	Mariana M. B. Azevedo
title	<i>Croton cajucara</i> Essential Oil Nanoemulsion and Its Antifungal Activities
title_short	<i>Croton cajucara</i> Essential Oil Nanoemulsion and Its Antifungal Activities
title_full	<i>Croton cajucara</i> Essential Oil Nanoemulsion and Its Antifungal Activities
title_fullStr	<i>Croton cajucara</i> Essential Oil Nanoemulsion and Its Antifungal Activities
title_full_unstemmed	<i>Croton cajucara</i> Essential Oil Nanoemulsion and Its Antifungal Activities
title_sort	<i>croton cajucara</i> essential oil nanoemulsion and its antifungal activities
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ab71a00481444b37a9ea0927df373040
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<i>Croton cajucara</i> Essential Oil Nanoemulsion and Its Antifungal Activities

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