Association between endometriosis and risk of systemic lupus erythematosus

Abstract To examine the association between endometriosis and the risk of systemic lupus erythematosus (SLE), this nationwide, population-based, retrospective cohort study was conducted based on National Health Insurance Research Database in Taiwan. Endometriosis (N = 16,758) and non-endometriosis (...

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Autores principales:	Yu-Hsi Fan, Pui-Ying Leong, Jeng-Yuan Chiou, Yu-Hsun Wang, Ming-Hsiang Ku, James Cheng-Chung Wei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ab759d780e58418aadf68a73bb374644
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spelling	oai:doaj.org-article:ab759d780e58418aadf68a73bb3746442021-12-02T15:22:59ZAssociation between endometriosis and risk of systemic lupus erythematosus10.1038/s41598-020-79954-z2045-2322https://doaj.org/article/ab759d780e58418aadf68a73bb3746442021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79954-zhttps://doaj.org/toc/2045-2322Abstract To examine the association between endometriosis and the risk of systemic lupus erythematosus (SLE), this nationwide, population-based, retrospective cohort study was conducted based on National Health Insurance Research Database in Taiwan. Endometriosis (N = 16,758) and non-endometriosis (N = 16,758) groups were identified by matching baseline characteristics and comorbidities. Student’s t-tests and the Kaplan–Meier estimator were utilized to estimate the hazard ratio (HR) and cumulative probability of SLE in the two groups. The endometriosis group showed a significantly higher incidence density rate (0.3 vs. 0.1 per 1000 person-years) and hazard ratio in SLE group (adjusted HR [aHR], 2.37; 95% confidence interval [CI] 1.35–4.14) compared to the non-endometriosis group. Subgroup analysis revealed that patients with endometriosis between 30 and 45 years of age, or were non-steroidal anti-inflammatory drug users, or were hormonal medications-free participants, had higher risks of SLE. For patients with endometriosis, surgical intervention did not significantly impact on the risk of SLE. Our results demonstrated an increased risk of SLE in patients with endometriosis. Clinicians should be aware of this association when managing patients with endometriosis or SLE.Yu-Hsi FanPui-Ying LeongJeng-Yuan ChiouYu-Hsun WangMing-Hsiang KuJames Cheng-Chung WeiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu-Hsi Fan Pui-Ying Leong Jeng-Yuan Chiou Yu-Hsun Wang Ming-Hsiang Ku James Cheng-Chung Wei Association between endometriosis and risk of systemic lupus erythematosus
description	Abstract To examine the association between endometriosis and the risk of systemic lupus erythematosus (SLE), this nationwide, population-based, retrospective cohort study was conducted based on National Health Insurance Research Database in Taiwan. Endometriosis (N = 16,758) and non-endometriosis (N = 16,758) groups were identified by matching baseline characteristics and comorbidities. Student’s t-tests and the Kaplan–Meier estimator were utilized to estimate the hazard ratio (HR) and cumulative probability of SLE in the two groups. The endometriosis group showed a significantly higher incidence density rate (0.3 vs. 0.1 per 1000 person-years) and hazard ratio in SLE group (adjusted HR [aHR], 2.37; 95% confidence interval [CI] 1.35–4.14) compared to the non-endometriosis group. Subgroup analysis revealed that patients with endometriosis between 30 and 45 years of age, or were non-steroidal anti-inflammatory drug users, or were hormonal medications-free participants, had higher risks of SLE. For patients with endometriosis, surgical intervention did not significantly impact on the risk of SLE. Our results demonstrated an increased risk of SLE in patients with endometriosis. Clinicians should be aware of this association when managing patients with endometriosis or SLE.
format	article
author	Yu-Hsi Fan Pui-Ying Leong Jeng-Yuan Chiou Yu-Hsun Wang Ming-Hsiang Ku James Cheng-Chung Wei
author_facet	Yu-Hsi Fan Pui-Ying Leong Jeng-Yuan Chiou Yu-Hsun Wang Ming-Hsiang Ku James Cheng-Chung Wei
author_sort	Yu-Hsi Fan
title	Association between endometriosis and risk of systemic lupus erythematosus
title_short	Association between endometriosis and risk of systemic lupus erythematosus
title_full	Association between endometriosis and risk of systemic lupus erythematosus
title_fullStr	Association between endometriosis and risk of systemic lupus erythematosus
title_full_unstemmed	Association between endometriosis and risk of systemic lupus erythematosus
title_sort	association between endometriosis and risk of systemic lupus erythematosus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ab759d780e58418aadf68a73bb374644
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Association between endometriosis and risk of systemic lupus erythematosus

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