Introducing intrauterine antibiotic infusion as a novel approach in effectively treating chronic endometritis and restoring reproductive dynamics: a randomized pilot study

Abstract The chronic nature of Chronic Endometritis (CE) along with the challenging management and infertility entailed, call for cutting-edge therapeutic approaches. This study introduces the novel treatment of intrauterine antibiotic infusion (IAI) combined with oral antibiotic administration (OAA...

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Autores principales:	Konstantinos Pantos, Mara Simopoulou, Evangelos Maziotis, Anna Rapani, Sokratis Grigoriadis, Petroula Tsioulou, Polina Giannelou, Nikolaos Nitsos, Panagiotis Tzonis, Michael Koutsilieris, Konstantinos Sfakianoudis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ab787600754e4ca48e839c55cb6ac7cf
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spelling	oai:doaj.org-article:ab787600754e4ca48e839c55cb6ac7cf2021-12-02T14:53:35ZIntroducing intrauterine antibiotic infusion as a novel approach in effectively treating chronic endometritis and restoring reproductive dynamics: a randomized pilot study10.1038/s41598-021-95072-w2045-2322https://doaj.org/article/ab787600754e4ca48e839c55cb6ac7cf2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95072-whttps://doaj.org/toc/2045-2322Abstract The chronic nature of Chronic Endometritis (CE) along with the challenging management and infertility entailed, call for cutting-edge therapeutic approaches. This study introduces the novel treatment of intrauterine antibiotic infusion (IAI) combined with oral antibiotic administration (OAA), and it assesses respective performance against the gold standard treatment of OAA. Data sourced herein reports on treatment efficiency and fertility restoration for both patients aiming to conceive naturally or via In Vitro fertilization. Eighty CE patients, 40 presenting with recurrent implantation failure, and 40 with recurrent pregnancy loss, were enrolled in the IVF and the natural conception arm respectively. Treatment was subjected to randomization. Effectively treated patients proceeded with either a single IVF cycle or were invited to conceive naturally over a 6-month period. Combination of IAI and OAA provided a statistically significant enhanced effectiveness treatment rate (RR 1.40; 95%CI 1.07–1.82; p = 0.01). No statistically significant difference was observed regarding the side-effects rate (RR 1.33; 95%CI 0.80–2.22; p = 0.52). No statistically significant difference was observed for either arm regarding live-birth rate. Following an intention-to-treat analysis, employment of IAI corresponds to improved clinical pregnancy rate-albeit not reaching statistical significance. In conclusion, complimentary implementation of IAI could provide a statistically significant enhanced clinical treatment outcome.Konstantinos PantosMara SimopoulouEvangelos MaziotisAnna RapaniSokratis GrigoriadisPetroula TsioulouPolina GiannelouNikolaos NitsosPanagiotis TzonisMichael KoutsilierisKonstantinos SfakianoudisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Konstantinos Pantos Mara Simopoulou Evangelos Maziotis Anna Rapani Sokratis Grigoriadis Petroula Tsioulou Polina Giannelou Nikolaos Nitsos Panagiotis Tzonis Michael Koutsilieris Konstantinos Sfakianoudis Introducing intrauterine antibiotic infusion as a novel approach in effectively treating chronic endometritis and restoring reproductive dynamics: a randomized pilot study
description	Abstract The chronic nature of Chronic Endometritis (CE) along with the challenging management and infertility entailed, call for cutting-edge therapeutic approaches. This study introduces the novel treatment of intrauterine antibiotic infusion (IAI) combined with oral antibiotic administration (OAA), and it assesses respective performance against the gold standard treatment of OAA. Data sourced herein reports on treatment efficiency and fertility restoration for both patients aiming to conceive naturally or via In Vitro fertilization. Eighty CE patients, 40 presenting with recurrent implantation failure, and 40 with recurrent pregnancy loss, were enrolled in the IVF and the natural conception arm respectively. Treatment was subjected to randomization. Effectively treated patients proceeded with either a single IVF cycle or were invited to conceive naturally over a 6-month period. Combination of IAI and OAA provided a statistically significant enhanced effectiveness treatment rate (RR 1.40; 95%CI 1.07–1.82; p = 0.01). No statistically significant difference was observed regarding the side-effects rate (RR 1.33; 95%CI 0.80–2.22; p = 0.52). No statistically significant difference was observed for either arm regarding live-birth rate. Following an intention-to-treat analysis, employment of IAI corresponds to improved clinical pregnancy rate-albeit not reaching statistical significance. In conclusion, complimentary implementation of IAI could provide a statistically significant enhanced clinical treatment outcome.
format	article
author	Konstantinos Pantos Mara Simopoulou Evangelos Maziotis Anna Rapani Sokratis Grigoriadis Petroula Tsioulou Polina Giannelou Nikolaos Nitsos Panagiotis Tzonis Michael Koutsilieris Konstantinos Sfakianoudis
author_facet	Konstantinos Pantos Mara Simopoulou Evangelos Maziotis Anna Rapani Sokratis Grigoriadis Petroula Tsioulou Polina Giannelou Nikolaos Nitsos Panagiotis Tzonis Michael Koutsilieris Konstantinos Sfakianoudis
author_sort	Konstantinos Pantos
title	Introducing intrauterine antibiotic infusion as a novel approach in effectively treating chronic endometritis and restoring reproductive dynamics: a randomized pilot study
title_short	Introducing intrauterine antibiotic infusion as a novel approach in effectively treating chronic endometritis and restoring reproductive dynamics: a randomized pilot study
title_full	Introducing intrauterine antibiotic infusion as a novel approach in effectively treating chronic endometritis and restoring reproductive dynamics: a randomized pilot study
title_fullStr	Introducing intrauterine antibiotic infusion as a novel approach in effectively treating chronic endometritis and restoring reproductive dynamics: a randomized pilot study
title_full_unstemmed	Introducing intrauterine antibiotic infusion as a novel approach in effectively treating chronic endometritis and restoring reproductive dynamics: a randomized pilot study
title_sort	introducing intrauterine antibiotic infusion as a novel approach in effectively treating chronic endometritis and restoring reproductive dynamics: a randomized pilot study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ab787600754e4ca48e839c55cb6ac7cf
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Introducing intrauterine antibiotic infusion as a novel approach in effectively treating chronic endometritis and restoring reproductive dynamics: a randomized pilot study

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