Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo

Abstract Metastatic cancer cells differ from their non-metastatic counterparts not only in terms of molecular composition and genetics, but also by the very strategy they employ for locomotion. Here, we analyzed large-scale statistics for cells migrating on linear microtracks to show that metastatic...

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Autores principales:	Sabil Huda, Bettina Weigelin, Katarina Wolf, Konstantin V. Tretiakov, Konstantin Polev, Gary Wilk, Masatomo Iwasa, Fateme S. Emami, Jakub W. Narojczyk, Michal Banaszak, Siowling Soh, Didzis Pilans, Amir Vahid, Monika Makurath, Peter Friedl, Gary G. Borisy, Kristiana Kandere-Grzybowska, Bartosz A. Grzybowski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ab7c60d120c14a229bca8cf384a52ad6
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spelling	oai:doaj.org-article:ab7c60d120c14a229bca8cf384a52ad62021-12-02T14:39:48ZLévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo10.1038/s41467-018-06563-w2041-1723https://doaj.org/article/ab7c60d120c14a229bca8cf384a52ad62018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06563-whttps://doaj.org/toc/2041-1723Abstract Metastatic cancer cells differ from their non-metastatic counterparts not only in terms of molecular composition and genetics, but also by the very strategy they employ for locomotion. Here, we analyzed large-scale statistics for cells migrating on linear microtracks to show that metastatic cancer cells follow a qualitatively different movement strategy than their non-invasive counterparts. The trajectories of metastatic cells display clusters of small steps that are interspersed with long “flights”. Such movements are characterized by heavy-tailed, truncated power law distributions of persistence times and are consistent with the Lévy walks that are also often employed by animal predators searching for scarce prey or food sources. In contrast, non-metastatic cancerous cells perform simple diffusive movements. These findings are supported by preliminary experiments with cancer cells migrating away from primary tumors in vivo. The use of chemical inhibitors targeting actin-binding proteins allows for “reprogramming” the Lévy walks into either diffusive or ballistic movements.Sabil HudaBettina WeigelinKatarina WolfKonstantin V. TretiakovKonstantin PolevGary WilkMasatomo IwasaFateme S. EmamiJakub W. NarojczykMichal BanaszakSiowling SohDidzis PilansAmir VahidMonika MakurathPeter FriedlGary G. BorisyKristiana Kandere-GrzybowskaBartosz A. GrzybowskiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sabil Huda Bettina Weigelin Katarina Wolf Konstantin V. Tretiakov Konstantin Polev Gary Wilk Masatomo Iwasa Fateme S. Emami Jakub W. Narojczyk Michal Banaszak Siowling Soh Didzis Pilans Amir Vahid Monika Makurath Peter Friedl Gary G. Borisy Kristiana Kandere-Grzybowska Bartosz A. Grzybowski Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo
description	Abstract Metastatic cancer cells differ from their non-metastatic counterparts not only in terms of molecular composition and genetics, but also by the very strategy they employ for locomotion. Here, we analyzed large-scale statistics for cells migrating on linear microtracks to show that metastatic cancer cells follow a qualitatively different movement strategy than their non-invasive counterparts. The trajectories of metastatic cells display clusters of small steps that are interspersed with long “flights”. Such movements are characterized by heavy-tailed, truncated power law distributions of persistence times and are consistent with the Lévy walks that are also often employed by animal predators searching for scarce prey or food sources. In contrast, non-metastatic cancerous cells perform simple diffusive movements. These findings are supported by preliminary experiments with cancer cells migrating away from primary tumors in vivo. The use of chemical inhibitors targeting actin-binding proteins allows for “reprogramming” the Lévy walks into either diffusive or ballistic movements.
format	article
author	Sabil Huda Bettina Weigelin Katarina Wolf Konstantin V. Tretiakov Konstantin Polev Gary Wilk Masatomo Iwasa Fateme S. Emami Jakub W. Narojczyk Michal Banaszak Siowling Soh Didzis Pilans Amir Vahid Monika Makurath Peter Friedl Gary G. Borisy Kristiana Kandere-Grzybowska Bartosz A. Grzybowski
author_facet	Sabil Huda Bettina Weigelin Katarina Wolf Konstantin V. Tretiakov Konstantin Polev Gary Wilk Masatomo Iwasa Fateme S. Emami Jakub W. Narojczyk Michal Banaszak Siowling Soh Didzis Pilans Amir Vahid Monika Makurath Peter Friedl Gary G. Borisy Kristiana Kandere-Grzybowska Bartosz A. Grzybowski
author_sort	Sabil Huda
title	Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo
title_short	Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo
title_full	Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo
title_fullStr	Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo
title_full_unstemmed	Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo
title_sort	lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ab7c60d120c14a229bca8cf384a52ad6
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Lévy-like movement patterns of metastatic cancer cells revealed in microfabricated systems and implicated in vivo

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