Anti-inflammatory adipokines: chemerin, vaspin, omentin concentrations and SARS-CoV-2 outcomes

Abstract Coronavirus disease 2019 (COVID-19) is associated with systemic inflammation. A wide range of adipokines activities suggests they influence pathogenesis and infection course. The aim was to assess concentrations of chemerin, omentin, and vaspin among COVID-19 patients with an emphasis on ad...

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Autores principales:	Michał Kukla, Tomasz Menżyk, Marcin Dembiński, Marek Winiarski, Aleksander Garlicki, Monika Bociąga-Jasik, Magdalena Skonieczna, Dorota Hudy, Barbara Maziarz, Beata Kusnierz-Cabala, Lubomir Skladany, Ivica Grgurevic, Małgorzata Wójcik-Bugajska, Tomasz Grodzicki, Dominika Stygar, Tomasz Rogula
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ab7ee6424fed4bea89e7d91ef4bfec76
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spelling	oai:doaj.org-article:ab7ee6424fed4bea89e7d91ef4bfec762021-11-08T10:49:14ZAnti-inflammatory adipokines: chemerin, vaspin, omentin concentrations and SARS-CoV-2 outcomes10.1038/s41598-021-00928-w2045-2322https://doaj.org/article/ab7ee6424fed4bea89e7d91ef4bfec762021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00928-whttps://doaj.org/toc/2045-2322Abstract Coronavirus disease 2019 (COVID-19) is associated with systemic inflammation. A wide range of adipokines activities suggests they influence pathogenesis and infection course. The aim was to assess concentrations of chemerin, omentin, and vaspin among COVID-19 patients with an emphasis on adipokines relationship with COVID-19 severity, concomitant metabolic abnormalities and liver dysfunction. Serum chemerin, omentin and vaspin concentrations were measured in serum collected from 70 COVID-19 patients at the moment of admission to hospital, before any treatment was applied and 20 healthy controls. Serum chemerin and omentin concentrations were significantly decreased in COVID-19 patients compared to healthy volunteers (271.0 vs. 373.0 ng/ml; p < 0.001 and 482.1 vs. 814.3 ng/ml; p = 0.01, respectively). There were no correlations of analyzed adipokines with COVID-19 severity based on the presence of pneumonia, dyspnea, or necessity of Intensive Care Unit hospitalization (ICU). Liver test abnormalities did not influence adipokines levels. Elevated GGT activity was associated with ICU admission, presence of pneumonia and elevated concentrations of CRP, ferritin and interleukin 6. Chemerin and omentin depletion in COVID-19 patients suggests that this adipokines deficiency play influential role in disease pathogenesis. However, there was no relationship between lower adipokines level and frequency of COVID-19 symptoms as well as disease severity. The only predictive factor which could predispose to a more severe COVID-19 course, including the presence of pneumonia and ICU hospitalization, was GGT activity.Michał KuklaTomasz MenżykMarcin DembińskiMarek WiniarskiAleksander GarlickiMonika Bociąga-JasikMagdalena SkoniecznaDorota HudyBarbara MaziarzBeata Kusnierz-CabalaLubomir SkladanyIvica GrgurevicMałgorzata Wójcik-BugajskaTomasz GrodzickiDominika StygarTomasz RogulaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michał Kukla Tomasz Menżyk Marcin Dembiński Marek Winiarski Aleksander Garlicki Monika Bociąga-Jasik Magdalena Skonieczna Dorota Hudy Barbara Maziarz Beata Kusnierz-Cabala Lubomir Skladany Ivica Grgurevic Małgorzata Wójcik-Bugajska Tomasz Grodzicki Dominika Stygar Tomasz Rogula Anti-inflammatory adipokines: chemerin, vaspin, omentin concentrations and SARS-CoV-2 outcomes
description	Abstract Coronavirus disease 2019 (COVID-19) is associated with systemic inflammation. A wide range of adipokines activities suggests they influence pathogenesis and infection course. The aim was to assess concentrations of chemerin, omentin, and vaspin among COVID-19 patients with an emphasis on adipokines relationship with COVID-19 severity, concomitant metabolic abnormalities and liver dysfunction. Serum chemerin, omentin and vaspin concentrations were measured in serum collected from 70 COVID-19 patients at the moment of admission to hospital, before any treatment was applied and 20 healthy controls. Serum chemerin and omentin concentrations were significantly decreased in COVID-19 patients compared to healthy volunteers (271.0 vs. 373.0 ng/ml; p < 0.001 and 482.1 vs. 814.3 ng/ml; p = 0.01, respectively). There were no correlations of analyzed adipokines with COVID-19 severity based on the presence of pneumonia, dyspnea, or necessity of Intensive Care Unit hospitalization (ICU). Liver test abnormalities did not influence adipokines levels. Elevated GGT activity was associated with ICU admission, presence of pneumonia and elevated concentrations of CRP, ferritin and interleukin 6. Chemerin and omentin depletion in COVID-19 patients suggests that this adipokines deficiency play influential role in disease pathogenesis. However, there was no relationship between lower adipokines level and frequency of COVID-19 symptoms as well as disease severity. The only predictive factor which could predispose to a more severe COVID-19 course, including the presence of pneumonia and ICU hospitalization, was GGT activity.
format	article
author	Michał Kukla Tomasz Menżyk Marcin Dembiński Marek Winiarski Aleksander Garlicki Monika Bociąga-Jasik Magdalena Skonieczna Dorota Hudy Barbara Maziarz Beata Kusnierz-Cabala Lubomir Skladany Ivica Grgurevic Małgorzata Wójcik-Bugajska Tomasz Grodzicki Dominika Stygar Tomasz Rogula
author_facet	Michał Kukla Tomasz Menżyk Marcin Dembiński Marek Winiarski Aleksander Garlicki Monika Bociąga-Jasik Magdalena Skonieczna Dorota Hudy Barbara Maziarz Beata Kusnierz-Cabala Lubomir Skladany Ivica Grgurevic Małgorzata Wójcik-Bugajska Tomasz Grodzicki Dominika Stygar Tomasz Rogula
author_sort	Michał Kukla
title	Anti-inflammatory adipokines: chemerin, vaspin, omentin concentrations and SARS-CoV-2 outcomes
title_short	Anti-inflammatory adipokines: chemerin, vaspin, omentin concentrations and SARS-CoV-2 outcomes
title_full	Anti-inflammatory adipokines: chemerin, vaspin, omentin concentrations and SARS-CoV-2 outcomes
title_fullStr	Anti-inflammatory adipokines: chemerin, vaspin, omentin concentrations and SARS-CoV-2 outcomes
title_full_unstemmed	Anti-inflammatory adipokines: chemerin, vaspin, omentin concentrations and SARS-CoV-2 outcomes
title_sort	anti-inflammatory adipokines: chemerin, vaspin, omentin concentrations and sars-cov-2 outcomes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ab7ee6424fed4bea89e7d91ef4bfec76
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Anti-inflammatory adipokines: chemerin, vaspin, omentin concentrations and SARS-CoV-2 outcomes

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