Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS)

Multiple chemical sensitivity (MCS) is a multisystem, recurrent, environmental disorder that flares in response to different exposures (i.e., pesticides, solvents, toxic metals and molds) under the threshold limit value (TLV) calculated for age and gender in the general population. MCS is a syndrome...

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Autores principales:	Giovanni Damiani, Marco Alessandrini, Daniela Caccamo, Andrea Cormano, Gianpaolo Guzzi, Andrea Mazzatenta, Alessandro Micarelli, Alberto Migliore, Alba Piroli, Margherita Bianca, Ottaviano Tapparo, Paolo Daniele Maria Pigatto
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	multiple chemical sensitivity (MCS) chemical intolerance threshold limit value environmental exposure neurogenic inflammation Medicine R
Acceso en línea:	https://doaj.org/article/ab7f0042b7c74d68aa24bd816e8fae72
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spelling	oai:doaj.org-article:ab7f0042b7c74d68aa24bd816e8fae722021-11-11T16:27:00ZItalian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS)10.3390/ijerph1821112941660-46011661-7827https://doaj.org/article/ab7f0042b7c74d68aa24bd816e8fae722021-10-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/21/11294https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Multiple chemical sensitivity (MCS) is a multisystem, recurrent, environmental disorder that flares in response to different exposures (i.e., pesticides, solvents, toxic metals and molds) under the threshold limit value (TLV) calculated for age and gender in the general population. MCS is a syndrome characterized by cutaneous, allergic, gastrointestinal, rheumatological, endocrinological, cardiological and neurological signs and symptoms. We performed a systematic review of the literature to summarize the current clinical and therapeutic evidence and then oriented an eDelphi consensus. Four main research domains were identified (diagnosis, treatment, hospitalization and emergency) and discussed by 10 experts and an MCS patient. Thus, the first Italian MCS consensus had the double aim: (a) to improve MCS knowledge among healthcare workers and patients by standardizing the clinical and therapeutic management to MCS patients; and (b) to improve and shed light on MCS misconceptions not supported by evidence-based medicine (EBM).Giovanni DamianiMarco AlessandriniDaniela CaccamoAndrea CormanoGianpaolo GuzziAndrea MazzatentaAlessandro MicarelliAlberto MiglioreAlba PiroliMargherita BiancaOttaviano TapparoPaolo Daniele Maria PigattoMDPI AGarticlemultiple chemical sensitivity (MCS)chemical intolerancethreshold limit valueenvironmental exposureneurogenic inflammationMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11294, p 11294 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	multiple chemical sensitivity (MCS) chemical intolerance threshold limit value environmental exposure neurogenic inflammation Medicine R
spellingShingle	multiple chemical sensitivity (MCS) chemical intolerance threshold limit value environmental exposure neurogenic inflammation Medicine R Giovanni Damiani Marco Alessandrini Daniela Caccamo Andrea Cormano Gianpaolo Guzzi Andrea Mazzatenta Alessandro Micarelli Alberto Migliore Alba Piroli Margherita Bianca Ottaviano Tapparo Paolo Daniele Maria Pigatto Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS)
description	Multiple chemical sensitivity (MCS) is a multisystem, recurrent, environmental disorder that flares in response to different exposures (i.e., pesticides, solvents, toxic metals and molds) under the threshold limit value (TLV) calculated for age and gender in the general population. MCS is a syndrome characterized by cutaneous, allergic, gastrointestinal, rheumatological, endocrinological, cardiological and neurological signs and symptoms. We performed a systematic review of the literature to summarize the current clinical and therapeutic evidence and then oriented an eDelphi consensus. Four main research domains were identified (diagnosis, treatment, hospitalization and emergency) and discussed by 10 experts and an MCS patient. Thus, the first Italian MCS consensus had the double aim: (a) to improve MCS knowledge among healthcare workers and patients by standardizing the clinical and therapeutic management to MCS patients; and (b) to improve and shed light on MCS misconceptions not supported by evidence-based medicine (EBM).
format	article
author	Giovanni Damiani Marco Alessandrini Daniela Caccamo Andrea Cormano Gianpaolo Guzzi Andrea Mazzatenta Alessandro Micarelli Alberto Migliore Alba Piroli Margherita Bianca Ottaviano Tapparo Paolo Daniele Maria Pigatto
author_facet	Giovanni Damiani Marco Alessandrini Daniela Caccamo Andrea Cormano Gianpaolo Guzzi Andrea Mazzatenta Alessandro Micarelli Alberto Migliore Alba Piroli Margherita Bianca Ottaviano Tapparo Paolo Daniele Maria Pigatto
author_sort	Giovanni Damiani
title	Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS)
title_short	Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS)
title_full	Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS)
title_fullStr	Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS)
title_full_unstemmed	Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS)
title_sort	italian expert consensus on clinical and therapeutic management of multiple chemical sensitivity (mcs)
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ab7f0042b7c74d68aa24bd816e8fae72
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Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS)

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