Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes
A main symptom of chronic insufficient sleep is excessive daytime sleepiness. Here, Wang et al. report 42 genome-wide significant loci for self-reported daytime sleepiness in 452,071 individuals from the UK Biobank that cluster into two biological subtypes of either sleep propensity or sleep fragmen...
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Nature Portfolio
2019
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oai:doaj.org-article:ab82094d6f1747f6b19a7f7da87c85b42021-12-02T17:32:39ZGenome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes10.1038/s41467-019-11456-72041-1723https://doaj.org/article/ab82094d6f1747f6b19a7f7da87c85b42019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11456-7https://doaj.org/toc/2041-1723A main symptom of chronic insufficient sleep is excessive daytime sleepiness. Here, Wang et al. report 42 genome-wide significant loci for self-reported daytime sleepiness in 452,071 individuals from the UK Biobank that cluster into two biological subtypes of either sleep propensity or sleep fragmentation.Heming WangJacqueline M. LaneSamuel E. JonesHassan S. DashtiHanna M. OllilaAndrew R. WoodVincent T. van HeesBen BrumptonBendik S. WinsvoldKatri KantojärviTeemu PalviainenBrian E. CadeTamar SoferYanwei SongKrunal PatelSimon G. AndersonDavid A. BechtoldJack BowdenRichard EmsleySimon D. KyleMax A. LittleAndrew S. LoudonFrank A. J. L. ScheerShaun M. PurcellRebecca C. RichmondKai SpiegelhalderJessica TyrrellXiaofeng ZhuChrister HublinJaakko A. KaprioKati KristianssonSonja SulkavaTiina PaunioKristian HveemJonas B. NielsenCristen J. WillerJohn-Anker ZwartLinn B. StrandTimothy M. FraylingDavid RayDeborah A. LawlorMartin K. RutterMichael N. WeedonSusan RedlineRicha SaxenaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Heming Wang Jacqueline M. Lane Samuel E. Jones Hassan S. Dashti Hanna M. Ollila Andrew R. Wood Vincent T. van Hees Ben Brumpton Bendik S. Winsvold Katri Kantojärvi Teemu Palviainen Brian E. Cade Tamar Sofer Yanwei Song Krunal Patel Simon G. Anderson David A. Bechtold Jack Bowden Richard Emsley Simon D. Kyle Max A. Little Andrew S. Loudon Frank A. J. L. Scheer Shaun M. Purcell Rebecca C. Richmond Kai Spiegelhalder Jessica Tyrrell Xiaofeng Zhu Christer Hublin Jaakko A. Kaprio Kati Kristiansson Sonja Sulkava Tiina Paunio Kristian Hveem Jonas B. Nielsen Cristen J. Willer John-Anker Zwart Linn B. Strand Timothy M. Frayling David Ray Deborah A. Lawlor Martin K. Rutter Michael N. Weedon Susan Redline Richa Saxena Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes |
| description |
A main symptom of chronic insufficient sleep is excessive daytime sleepiness. Here, Wang et al. report 42 genome-wide significant loci for self-reported daytime sleepiness in 452,071 individuals from the UK Biobank that cluster into two biological subtypes of either sleep propensity or sleep fragmentation. |
| format |
article |
| author |
Heming Wang Jacqueline M. Lane Samuel E. Jones Hassan S. Dashti Hanna M. Ollila Andrew R. Wood Vincent T. van Hees Ben Brumpton Bendik S. Winsvold Katri Kantojärvi Teemu Palviainen Brian E. Cade Tamar Sofer Yanwei Song Krunal Patel Simon G. Anderson David A. Bechtold Jack Bowden Richard Emsley Simon D. Kyle Max A. Little Andrew S. Loudon Frank A. J. L. Scheer Shaun M. Purcell Rebecca C. Richmond Kai Spiegelhalder Jessica Tyrrell Xiaofeng Zhu Christer Hublin Jaakko A. Kaprio Kati Kristiansson Sonja Sulkava Tiina Paunio Kristian Hveem Jonas B. Nielsen Cristen J. Willer John-Anker Zwart Linn B. Strand Timothy M. Frayling David Ray Deborah A. Lawlor Martin K. Rutter Michael N. Weedon Susan Redline Richa Saxena |
| author_facet |
Heming Wang Jacqueline M. Lane Samuel E. Jones Hassan S. Dashti Hanna M. Ollila Andrew R. Wood Vincent T. van Hees Ben Brumpton Bendik S. Winsvold Katri Kantojärvi Teemu Palviainen Brian E. Cade Tamar Sofer Yanwei Song Krunal Patel Simon G. Anderson David A. Bechtold Jack Bowden Richard Emsley Simon D. Kyle Max A. Little Andrew S. Loudon Frank A. J. L. Scheer Shaun M. Purcell Rebecca C. Richmond Kai Spiegelhalder Jessica Tyrrell Xiaofeng Zhu Christer Hublin Jaakko A. Kaprio Kati Kristiansson Sonja Sulkava Tiina Paunio Kristian Hveem Jonas B. Nielsen Cristen J. Willer John-Anker Zwart Linn B. Strand Timothy M. Frayling David Ray Deborah A. Lawlor Martin K. Rutter Michael N. Weedon Susan Redline Richa Saxena |
| author_sort |
Heming Wang |
| title |
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes |
| title_short |
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes |
| title_full |
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes |
| title_fullStr |
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes |
| title_full_unstemmed |
Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes |
| title_sort |
genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/ab82094d6f1747f6b19a7f7da87c85b4 |
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