A New Paradigm for KIM-PTP Drug Discovery: Identification of Allosteric Sites with Potential for Selective Inhibition Using Virtual Screening and LEI Analysis
The kinase interaction motif protein tyrosine phosphatases (KIM-PTPs), HePTP, PTPSL and STEP, are involved in the negative regulation of mitogen-activated protein kinase (MAPK) signalling pathways and are important therapeutic targets for a number of diseases. We have used VSpipe, a virtual screenin...
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Formato: | article |
Lenguaje: | EN |
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MDPI AG
2021
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Acceso en línea: | https://doaj.org/article/ab829902ca984b639efe0a6115fa4ba4 |
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