Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model

Dissemination of tumor cells from the primary site is an early event. Here, the authors show that the early disseminated tumor cells are actively cleared by the host cytotoxic T lymphocytes induced by the primary tumor and that infiltration of granulocytic myeloid-derived suppressor cells counteract...

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Autores principales:	Raziye Piranlioglu, EunMi Lee, Maria Ouzounova, Roni J. Bollag, Alicia H. Vinyard, Ali S. Arbab, Daniela Marasco, Mustafa Guzel, John K. Cowell, Muthushamy Thangaraju, Ahmed Chadli, Khaled A. Hassan, Max S. Wicha, Esteban Celis, Hasan Korkaya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ab8309125be1466c9f20adaacc94d582
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spelling	oai:doaj.org-article:ab8309125be1466c9f20adaacc94d5822021-12-02T17:32:40ZPrimary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model10.1038/s41467-019-09015-12041-1723https://doaj.org/article/ab8309125be1466c9f20adaacc94d5822019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09015-1https://doaj.org/toc/2041-1723Dissemination of tumor cells from the primary site is an early event. Here, the authors show that the early disseminated tumor cells are actively cleared by the host cytotoxic T lymphocytes induced by the primary tumor and that infiltration of granulocytic myeloid-derived suppressor cells counteracts such immune protection and allow metastasis development.Raziye PiranliogluEunMi LeeMaria OuzounovaRoni J. BollagAlicia H. VinyardAli S. ArbabDaniela MarascoMustafa GuzelJohn K. CowellMuthushamy ThangarajuAhmed ChadliKhaled A. HassanMax S. WichaEsteban CelisHasan KorkayaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Raziye Piranlioglu EunMi Lee Maria Ouzounova Roni J. Bollag Alicia H. Vinyard Ali S. Arbab Daniela Marasco Mustafa Guzel John K. Cowell Muthushamy Thangaraju Ahmed Chadli Khaled A. Hassan Max S. Wicha Esteban Celis Hasan Korkaya Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model
description	Dissemination of tumor cells from the primary site is an early event. Here, the authors show that the early disseminated tumor cells are actively cleared by the host cytotoxic T lymphocytes induced by the primary tumor and that infiltration of granulocytic myeloid-derived suppressor cells counteracts such immune protection and allow metastasis development.
format	article
author	Raziye Piranlioglu EunMi Lee Maria Ouzounova Roni J. Bollag Alicia H. Vinyard Ali S. Arbab Daniela Marasco Mustafa Guzel John K. Cowell Muthushamy Thangaraju Ahmed Chadli Khaled A. Hassan Max S. Wicha Esteban Celis Hasan Korkaya
author_facet	Raziye Piranlioglu EunMi Lee Maria Ouzounova Roni J. Bollag Alicia H. Vinyard Ali S. Arbab Daniela Marasco Mustafa Guzel John K. Cowell Muthushamy Thangaraju Ahmed Chadli Khaled A. Hassan Max S. Wicha Esteban Celis Hasan Korkaya
author_sort	Raziye Piranlioglu
title	Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model
title_short	Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model
title_full	Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model
title_fullStr	Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model
title_full_unstemmed	Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model
title_sort	primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ab8309125be1466c9f20adaacc94d582
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Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model

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