Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

Genetics implicate microglia in Alzheimer’s disease pathogenesis, but their roles remain unclear. Here, the authors find that microglial depletion in a mouse model of Alzheimer’s disease impairs plaque formation and that Aβ-induced changes in neuronal gene expression are microglia-mediated.

Guardado en:

Detalles Bibliográficos
Autores principales:	Elizabeth Spangenberg, Paul L. Severson, Lindsay A. Hohsfield, Joshua Crapser, Jiazhong Zhang, Elizabeth A. Burton, Ying Zhang, Wayne Spevak, Jack Lin, Nicole Y. Phan, Gaston Habets, Andrey Rymar, Garson Tsang, Jason Walters, Marika Nespi, Parmveer Singh, Stephanie Broome, Prabha Ibrahim, Chao Zhang, Gideon Bollag, Brian L. West, Kim N. Green
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ab83dec7482d44a28b96b168ea75f0ff
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ab83dec7482d44a28b96b168ea75f0ff
record_format	dspace
spelling	oai:doaj.org-article:ab83dec7482d44a28b96b168ea75f0ff2021-12-02T17:32:55ZSustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model10.1038/s41467-019-11674-z2041-1723https://doaj.org/article/ab83dec7482d44a28b96b168ea75f0ff2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11674-zhttps://doaj.org/toc/2041-1723Genetics implicate microglia in Alzheimer’s disease pathogenesis, but their roles remain unclear. Here, the authors find that microglial depletion in a mouse model of Alzheimer’s disease impairs plaque formation and that Aβ-induced changes in neuronal gene expression are microglia-mediated.Elizabeth SpangenbergPaul L. SeversonLindsay A. HohsfieldJoshua CrapserJiazhong ZhangElizabeth A. BurtonYing ZhangWayne SpevakJack LinNicole Y. PhanGaston HabetsAndrey RymarGarson TsangJason WaltersMarika NespiParmveer SinghStephanie BroomePrabha IbrahimChao ZhangGideon BollagBrian L. WestKim N. GreenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-21 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elizabeth Spangenberg Paul L. Severson Lindsay A. Hohsfield Joshua Crapser Jiazhong Zhang Elizabeth A. Burton Ying Zhang Wayne Spevak Jack Lin Nicole Y. Phan Gaston Habets Andrey Rymar Garson Tsang Jason Walters Marika Nespi Parmveer Singh Stephanie Broome Prabha Ibrahim Chao Zhang Gideon Bollag Brian L. West Kim N. Green Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model
description	Genetics implicate microglia in Alzheimer’s disease pathogenesis, but their roles remain unclear. Here, the authors find that microglial depletion in a mouse model of Alzheimer’s disease impairs plaque formation and that Aβ-induced changes in neuronal gene expression are microglia-mediated.
format	article
author	Elizabeth Spangenberg Paul L. Severson Lindsay A. Hohsfield Joshua Crapser Jiazhong Zhang Elizabeth A. Burton Ying Zhang Wayne Spevak Jack Lin Nicole Y. Phan Gaston Habets Andrey Rymar Garson Tsang Jason Walters Marika Nespi Parmveer Singh Stephanie Broome Prabha Ibrahim Chao Zhang Gideon Bollag Brian L. West Kim N. Green
author_facet	Elizabeth Spangenberg Paul L. Severson Lindsay A. Hohsfield Joshua Crapser Jiazhong Zhang Elizabeth A. Burton Ying Zhang Wayne Spevak Jack Lin Nicole Y. Phan Gaston Habets Andrey Rymar Garson Tsang Jason Walters Marika Nespi Parmveer Singh Stephanie Broome Prabha Ibrahim Chao Zhang Gideon Bollag Brian L. West Kim N. Green
author_sort	Elizabeth Spangenberg
title	Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model
title_short	Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model
title_full	Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model
title_fullStr	Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model
title_full_unstemmed	Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model
title_sort	sustained microglial depletion with csf1r inhibitor impairs parenchymal plaque development in an alzheimer’s disease model
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ab83dec7482d44a28b96b168ea75f0ff
work_keys_str_mv	AT elizabethspangenberg sustainedmicroglialdepletionwithcsf1rinhibitorimpairsparenchymalplaquedevelopmentinanalzheimersdiseasemodel AT paullseverson sustainedmicroglialdepletionwithcsf1rinhibitorimpairsparenchymalplaquedevelopmentinanalzheimersdiseasemodel AT lindsayahohsfield sustainedmicroglialdepletionwithcsf1rinhibitorimpairsparenchymalplaquedevelopmentinanalzheimersdiseasemodel AT joshuacrapser sustainedmicroglialdepletionwithcsf1rinhibitorimpairsparenchymalplaquedevelopmentinanalzheimersdiseasemodel AT jiazhongzhang sustainedmicroglialdepletionwithcsf1rinhibitorimpairsparenchymalplaquedevelopmentinanalzheimersdiseasemodel AT elizabethaburton sustainedmicroglialdepletionwithcsf1rinhibitorimpairsparenchymalplaquedevelopmentinanalzheimersdiseasemodel AT yingzhang sustainedmicroglialdepletionwithcsf1rinhibitorimpairsparenchymalplaquedevelopmentinanalzheimersdiseasemodel AT waynespevak sustainedmicroglialdepletionwithcsf1rinhibitorimpairsparenchymalplaquedevelopmentinanalzheimersdiseasemodel AT jacklin sustainedmicroglialdepletionwithcsf1rinhibitorimpairsparenchymalplaquedevelopmentinanalzheimersdiseasemodel AT nicoleyphan sustainedmicroglialdepletionwithcsf1rinhibitorimpairsparenchymalplaquedevelopmentinanalzheimersdiseasemodel AT gastonhabets sustainedmicroglialdepletionwithcsf1rinhibitorimpairsparenchymalplaquedevelopmentinanalzheimersdiseasemodel AT andreyrymar sustainedmicroglialdepletionwithcsf1rinhibitorimpairsparenchymalplaquedevelopmentinanalzheimersdiseasemodel AT garsontsang sustainedmicroglialdepletionwithcsf1rinhibitorimpairsparenchymalplaquedevelopmentinanalzheimersdiseasemodel AT jasonwalters sustainedmicroglialdepletionwithcsf1rinhibitorimpairsparenchymalplaquedevelopmentinanalzheimersdiseasemodel AT marikanespi sustainedmicroglialdepletionwithcsf1rinhibitorimpairsparenchymalplaquedevelopmentinanalzheimersdiseasemodel AT parmveersingh sustainedmicroglialdepletionwithcsf1rinhibitorimpairsparenchymalplaquedevelopmentinanalzheimersdiseasemodel AT stephaniebroome sustainedmicroglialdepletionwithcsf1rinhibitorimpairsparenchymalplaquedevelopmentinanalzheimersdiseasemodel AT prabhaibrahim sustainedmicroglialdepletionwithcsf1rinhibitorimpairsparenchymalplaquedevelopmentinanalzheimersdiseasemodel AT chaozhang sustainedmicroglialdepletionwithcsf1rinhibitorimpairsparenchymalplaquedevelopmentinanalzheimersdiseasemodel AT gideonbollag sustainedmicroglialdepletionwithcsf1rinhibitorimpairsparenchymalplaquedevelopmentinanalzheimersdiseasemodel AT brianlwest sustainedmicroglialdepletionwithcsf1rinhibitorimpairsparenchymalplaquedevelopmentinanalzheimersdiseasemodel AT kimngreen sustainedmicroglialdepletionwithcsf1rinhibitorimpairsparenchymalplaquedevelopmentinanalzheimersdiseasemodel
_version_	1718380141038534656

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

Ejemplares similares