Short intense psychological stress induced by skydiving does not impair intestinal barrier function.

<h4>Background and aim</h4>Psychological stress has been shown to increase intestinal permeability and is associated with the development of gastrointestinal disorders. This study aimed to investigate skydiving as an alternative model to analyse the effect of acute psychological stress o...

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Autores principales:	Maria Fernanda Roca Rubio, Ulrika Eriksson, Robert J Brummer, Julia König
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ab85a5cbc2ea428696474564555511dd
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spelling	oai:doaj.org-article:ab85a5cbc2ea428696474564555511dd2021-12-02T20:19:39ZShort intense psychological stress induced by skydiving does not impair intestinal barrier function.1932-620310.1371/journal.pone.0254280https://doaj.org/article/ab85a5cbc2ea428696474564555511dd2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254280https://doaj.org/toc/1932-6203<h4>Background and aim</h4>Psychological stress has been shown to increase intestinal permeability and is associated with the development of gastrointestinal disorders. This study aimed to investigate skydiving as an alternative model to analyse the effect of acute psychological stress on intestinal barrier function.<h4>Materials and methods</h4>Twenty healthy subjects participated in a tandem skydive followed by a negative control visit, of which 19 (9 females and 10 males, 25.9 ± 3.7 years) were included in the study. Intestinal permeability was assessed by a multi-sugar urinary recovery test. Sucrose recovery and lactulose/rhamnose ratio in 0-5h urine indicated gastroduodenal and small intestinal permeability, respectively, and sucralose/erythritol ratio in 5-24h urine indicated colonic permeability. Blood samples were taken to assess markers associated with barrier function. This study has been registered at ClinicalTrials.gov (NCT03644979) on August 23, 2018.<h4>Results</h4>Skydiving resulted in a significant increase in salivary cortisol levels directly after skydiving compared to the control visit. Cortisol levels were still increased two hours after landing, while cortisol levels before skydiving were not significantly different from the baseline at the control visit. Skydiving did not induce a significant increase in gastroduodenal, small intestinal or colonic permeability. There was also no significant increase in plasma intestinal and liver fatty acid-binding proteins, suggesting no damage to the enterocytes.<h4>Discussion</h4>These results show that the acute intense psychological stress induced by skydiving does not affect intestinal permeability in healthy subjects. Future models aiming to investigate the effect of stress on human intestinal barrier function should consider a more sustained exposure to the psychological stressor.Maria Fernanda Roca RubioUlrika ErikssonRobert J BrummerJulia KönigPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254280 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria Fernanda Roca Rubio Ulrika Eriksson Robert J Brummer Julia König Short intense psychological stress induced by skydiving does not impair intestinal barrier function.
description	<h4>Background and aim</h4>Psychological stress has been shown to increase intestinal permeability and is associated with the development of gastrointestinal disorders. This study aimed to investigate skydiving as an alternative model to analyse the effect of acute psychological stress on intestinal barrier function.<h4>Materials and methods</h4>Twenty healthy subjects participated in a tandem skydive followed by a negative control visit, of which 19 (9 females and 10 males, 25.9 ± 3.7 years) were included in the study. Intestinal permeability was assessed by a multi-sugar urinary recovery test. Sucrose recovery and lactulose/rhamnose ratio in 0-5h urine indicated gastroduodenal and small intestinal permeability, respectively, and sucralose/erythritol ratio in 5-24h urine indicated colonic permeability. Blood samples were taken to assess markers associated with barrier function. This study has been registered at ClinicalTrials.gov (NCT03644979) on August 23, 2018.<h4>Results</h4>Skydiving resulted in a significant increase in salivary cortisol levels directly after skydiving compared to the control visit. Cortisol levels were still increased two hours after landing, while cortisol levels before skydiving were not significantly different from the baseline at the control visit. Skydiving did not induce a significant increase in gastroduodenal, small intestinal or colonic permeability. There was also no significant increase in plasma intestinal and liver fatty acid-binding proteins, suggesting no damage to the enterocytes.<h4>Discussion</h4>These results show that the acute intense psychological stress induced by skydiving does not affect intestinal permeability in healthy subjects. Future models aiming to investigate the effect of stress on human intestinal barrier function should consider a more sustained exposure to the psychological stressor.
format	article
author	Maria Fernanda Roca Rubio Ulrika Eriksson Robert J Brummer Julia König
author_facet	Maria Fernanda Roca Rubio Ulrika Eriksson Robert J Brummer Julia König
author_sort	Maria Fernanda Roca Rubio
title	Short intense psychological stress induced by skydiving does not impair intestinal barrier function.
title_short	Short intense psychological stress induced by skydiving does not impair intestinal barrier function.
title_full	Short intense psychological stress induced by skydiving does not impair intestinal barrier function.
title_fullStr	Short intense psychological stress induced by skydiving does not impair intestinal barrier function.
title_full_unstemmed	Short intense psychological stress induced by skydiving does not impair intestinal barrier function.
title_sort	short intense psychological stress induced by skydiving does not impair intestinal barrier function.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/ab85a5cbc2ea428696474564555511dd
work_keys_str_mv	AT mariafernandarocarubio shortintensepsychologicalstressinducedbyskydivingdoesnotimpairintestinalbarrierfunction AT ulrikaeriksson shortintensepsychologicalstressinducedbyskydivingdoesnotimpairintestinalbarrierfunction AT robertjbrummer shortintensepsychologicalstressinducedbyskydivingdoesnotimpairintestinalbarrierfunction AT juliakonig shortintensepsychologicalstressinducedbyskydivingdoesnotimpairintestinalbarrierfunction
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Short intense psychological stress induced by skydiving does not impair intestinal barrier function.

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