The Risk Factors of Puberty Precocious in Girls: Is the Condition Related with Polychlorobiphenyls?

Aim:Our aim was investigate the effect of polychlorobifenyls (PCBs) and other factors on puberty precocious (PP) in girls were diagnosed with idiopatic PP and premature thelarche (PT).Materials and Methods:The study group included 50 girls aged between 2-8 years old with PP and PT. The control group...

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Autores principales:	Raziye Burcu Güven Bilgin, Samim Özen, Ruhsar Damla Gökşen, Özlem Korkmaz, Şükran Darcan
Formato:	article
Lenguaje:	EN TR
Publicado:	Galenos Yayinevi 2021
Materias:	puberty precocious premature thelarche environmental endocrine distrubs polychlorobifenyl obesity Medicine R Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/ab85d010e1a346bea1a6168b8719d4b0
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spelling	oai:doaj.org-article:ab85d010e1a346bea1a6168b8719d4b02021-11-11T11:27:23ZThe Risk Factors of Puberty Precocious in Girls: Is the Condition Related with Polychlorobiphenyls?2147-94452587-247810.4274/jpr.galenos.2021.67689https://doaj.org/article/ab85d010e1a346bea1a6168b8719d4b02021-12-01T00:00:00Z http://jpedres.org/archives/archive-detail/article-preview/the-risk-factors-of-puberty-precocious-in-girls-s-/49634 https://doaj.org/toc/2147-9445https://doaj.org/toc/2587-2478Aim:Our aim was investigate the effect of polychlorobifenyls (PCBs) and other factors on puberty precocious (PP) in girls were diagnosed with idiopatic PP and premature thelarche (PT).Materials and Methods:The study group included 50 girls aged between 2-8 years old with PP and PT. The control group included 50 healthy girls with same age range and no puberty findings. Data was collected in terms of breast and pubic hair stages, weight, height, body mass index (BMI), standard deviation scores (SDSs), location of residence, gestational age and maternal age at menarche (AAM). Twenty-one PCB levels were evaluated in serum and urine. One-Way ANOVA test was used for comparison between the groups. For subgroup analysis, Mann-Whitney U test, multiple regression analysis were used.Results:The mean age of the study and control groups were 6.70±1.20 and 5.23±1.25 years, respectively. The studied PCBs were not detectable found in either the study or the control groups. The BMI SDSs of the patients in study and healthy groups were 0.49±1.09 and -0.12±1.28, respectively (p=0.1). Weight SDSs in the study group were found to be significantly higher than healthy group (0.72±1.35 vs -0.20±1.47, p=0.008 Maternal AAM of the patients in study group was significantly lower (p=0.006). In study group 98% of the patients were living in down town and district, whereas this ratio was 92% in control group (p=0.024). In study group 29 patients (58%) were diagnosed with PT. Basal follicle stimulating hormone and estradiol levels, bone age and uterine longest axis dimensions results were significantly different.Conclusion:We found that studied PCBs don't influence on PP in girls aged between 2-8 years old. However, weight SDS, maternal AAM, location of residence of the patients had a significant role on PP in this patient population.Raziye Burcu Güven BilginSamim ÖzenRuhsar Damla GökşenÖzlem KorkmazŞükran DarcanGalenos Yayineviarticlepuberty precociouspremature thelarcheenvironmental endocrine distrubspolychlorobifenylobesityMedicineRPediatricsRJ1-570ENTRJournal of Pediatric Research, Vol 8, Iss 4, Pp 408-413 (2021)
institution	DOAJ
collection	DOAJ
language	EN TR
topic	puberty precocious premature thelarche environmental endocrine distrubs polychlorobifenyl obesity Medicine R Pediatrics RJ1-570
spellingShingle	puberty precocious premature thelarche environmental endocrine distrubs polychlorobifenyl obesity Medicine R Pediatrics RJ1-570 Raziye Burcu Güven Bilgin Samim Özen Ruhsar Damla Gökşen Özlem Korkmaz Şükran Darcan The Risk Factors of Puberty Precocious in Girls: Is the Condition Related with Polychlorobiphenyls?
description	Aim:Our aim was investigate the effect of polychlorobifenyls (PCBs) and other factors on puberty precocious (PP) in girls were diagnosed with idiopatic PP and premature thelarche (PT).Materials and Methods:The study group included 50 girls aged between 2-8 years old with PP and PT. The control group included 50 healthy girls with same age range and no puberty findings. Data was collected in terms of breast and pubic hair stages, weight, height, body mass index (BMI), standard deviation scores (SDSs), location of residence, gestational age and maternal age at menarche (AAM). Twenty-one PCB levels were evaluated in serum and urine. One-Way ANOVA test was used for comparison between the groups. For subgroup analysis, Mann-Whitney U test, multiple regression analysis were used.Results:The mean age of the study and control groups were 6.70±1.20 and 5.23±1.25 years, respectively. The studied PCBs were not detectable found in either the study or the control groups. The BMI SDSs of the patients in study and healthy groups were 0.49±1.09 and -0.12±1.28, respectively (p=0.1). Weight SDSs in the study group were found to be significantly higher than healthy group (0.72±1.35 vs -0.20±1.47, p=0.008 Maternal AAM of the patients in study group was significantly lower (p=0.006). In study group 98% of the patients were living in down town and district, whereas this ratio was 92% in control group (p=0.024). In study group 29 patients (58%) were diagnosed with PT. Basal follicle stimulating hormone and estradiol levels, bone age and uterine longest axis dimensions results were significantly different.Conclusion:We found that studied PCBs don't influence on PP in girls aged between 2-8 years old. However, weight SDS, maternal AAM, location of residence of the patients had a significant role on PP in this patient population.
format	article
author	Raziye Burcu Güven Bilgin Samim Özen Ruhsar Damla Gökşen Özlem Korkmaz Şükran Darcan
author_facet	Raziye Burcu Güven Bilgin Samim Özen Ruhsar Damla Gökşen Özlem Korkmaz Şükran Darcan
author_sort	Raziye Burcu Güven Bilgin
title	The Risk Factors of Puberty Precocious in Girls: Is the Condition Related with Polychlorobiphenyls?
title_short	The Risk Factors of Puberty Precocious in Girls: Is the Condition Related with Polychlorobiphenyls?
title_full	The Risk Factors of Puberty Precocious in Girls: Is the Condition Related with Polychlorobiphenyls?
title_fullStr	The Risk Factors of Puberty Precocious in Girls: Is the Condition Related with Polychlorobiphenyls?
title_full_unstemmed	The Risk Factors of Puberty Precocious in Girls: Is the Condition Related with Polychlorobiphenyls?
title_sort	risk factors of puberty precocious in girls: is the condition related with polychlorobiphenyls?
publisher	Galenos Yayinevi
publishDate	2021
url	https://doaj.org/article/ab85d010e1a346bea1a6168b8719d4b0
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The Risk Factors of Puberty Precocious in Girls: Is the Condition Related with Polychlorobiphenyls?

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