Capnography monitoring the hypoventilation during the induction of bronchoscopic sedation: A randomized controlled trial

Abstract We hypothesize that capnography could detect hypoventilation during induction of bronchoscopic sedation and starting bronchoscopy following hypoventilation, may decrease hypoxemia. Patients were randomized to: starting bronchoscopy when hypoventilation (hypopnea, two successive breaths of a...

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Autores principales:	Ting-Yu Lin, Yueh-Fu Fang, Shih-Hao Huang, Tsai-Yu Wang, Chih-Hsi Kuo, Hau-Tieng Wu, Han-Pin Kuo, Yu-Lun Lo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ab88d4acb702427f968d1fe166d2fd01
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spelling	oai:doaj.org-article:ab88d4acb702427f968d1fe166d2fd012021-12-02T16:07:02ZCapnography monitoring the hypoventilation during the induction of bronchoscopic sedation: A randomized controlled trial10.1038/s41598-017-09082-82045-2322https://doaj.org/article/ab88d4acb702427f968d1fe166d2fd012017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09082-8https://doaj.org/toc/2045-2322Abstract We hypothesize that capnography could detect hypoventilation during induction of bronchoscopic sedation and starting bronchoscopy following hypoventilation, may decrease hypoxemia. Patients were randomized to: starting bronchoscopy when hypoventilation (hypopnea, two successive breaths of at least 50% reduction of the peak wave compared to baseline or apnea, no wave for 10 seconds) (Study group, n = 55), or when the Observer Assessment of Alertness and Sedation scale (OAAS) was less than 4 (Control group, n = 59). Propofol infusion was titrated to maintain stable vital signs and sedative levels. The hypoventilation during induction in the control group and the sedative outcome were recorded. The patient characteristics and procedures performed were similar. Hypoventilation was observed in 74.6% of the patients before achieving OAAS < 4 in the control group. Apnea occurred more than hypopnea (p < 0.0001). Hypoventilation preceded OAAS < 4 by 96.5 ± 88.1 seconds. In the study group, the induction time was shorter (p = 0.03) and subjects with any two events of hypoxemia during sedation, maintenance or recovery were less than the control group (1.8 vs. 18.6%, p < 0.01). Patient tolerance, wakefulness during sedation, and cooperation were similar in both groups. Significant hypoventilation occurred during the induction and start bronchoscopy following hypoventilation may decrease hypoxemia without compromising patient tolerance.Ting-Yu LinYueh-Fu FangShih-Hao HuangTsai-Yu WangChih-Hsi KuoHau-Tieng WuHan-Pin KuoYu-Lun LoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ting-Yu Lin Yueh-Fu Fang Shih-Hao Huang Tsai-Yu Wang Chih-Hsi Kuo Hau-Tieng Wu Han-Pin Kuo Yu-Lun Lo Capnography monitoring the hypoventilation during the induction of bronchoscopic sedation: A randomized controlled trial
description	Abstract We hypothesize that capnography could detect hypoventilation during induction of bronchoscopic sedation and starting bronchoscopy following hypoventilation, may decrease hypoxemia. Patients were randomized to: starting bronchoscopy when hypoventilation (hypopnea, two successive breaths of at least 50% reduction of the peak wave compared to baseline or apnea, no wave for 10 seconds) (Study group, n = 55), or when the Observer Assessment of Alertness and Sedation scale (OAAS) was less than 4 (Control group, n = 59). Propofol infusion was titrated to maintain stable vital signs and sedative levels. The hypoventilation during induction in the control group and the sedative outcome were recorded. The patient characteristics and procedures performed were similar. Hypoventilation was observed in 74.6% of the patients before achieving OAAS < 4 in the control group. Apnea occurred more than hypopnea (p < 0.0001). Hypoventilation preceded OAAS < 4 by 96.5 ± 88.1 seconds. In the study group, the induction time was shorter (p = 0.03) and subjects with any two events of hypoxemia during sedation, maintenance or recovery were less than the control group (1.8 vs. 18.6%, p < 0.01). Patient tolerance, wakefulness during sedation, and cooperation were similar in both groups. Significant hypoventilation occurred during the induction and start bronchoscopy following hypoventilation may decrease hypoxemia without compromising patient tolerance.
format	article
author	Ting-Yu Lin Yueh-Fu Fang Shih-Hao Huang Tsai-Yu Wang Chih-Hsi Kuo Hau-Tieng Wu Han-Pin Kuo Yu-Lun Lo
author_facet	Ting-Yu Lin Yueh-Fu Fang Shih-Hao Huang Tsai-Yu Wang Chih-Hsi Kuo Hau-Tieng Wu Han-Pin Kuo Yu-Lun Lo
author_sort	Ting-Yu Lin
title	Capnography monitoring the hypoventilation during the induction of bronchoscopic sedation: A randomized controlled trial
title_short	Capnography monitoring the hypoventilation during the induction of bronchoscopic sedation: A randomized controlled trial
title_full	Capnography monitoring the hypoventilation during the induction of bronchoscopic sedation: A randomized controlled trial
title_fullStr	Capnography monitoring the hypoventilation during the induction of bronchoscopic sedation: A randomized controlled trial
title_full_unstemmed	Capnography monitoring the hypoventilation during the induction of bronchoscopic sedation: A randomized controlled trial
title_sort	capnography monitoring the hypoventilation during the induction of bronchoscopic sedation: a randomized controlled trial
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ab88d4acb702427f968d1fe166d2fd01
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Capnography monitoring the hypoventilation during the induction of bronchoscopic sedation: A randomized controlled trial

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