Noninvasive thrombectomy of graft by nano-magnetic ablating particles

Abstract Artificial vascular treatment is an emerging interdisciplinary subject of medicine. Although the use of artificial vessels has led to many successful advancements, blood clotting remains a major challenge, especially in terms of mural clots created along the vessel wall that do not complete...

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Autores principales:	Abbas Moghanizadeh, Fakhreddin Ashrafizadeh, Jaleh Varshosaz, Mahshid Kharaziha, Antoine Ferreira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ab892eb9a67d43f2b7d74863b5c1f43e
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spelling	oai:doaj.org-article:ab892eb9a67d43f2b7d74863b5c1f43e2021-12-02T13:24:26ZNoninvasive thrombectomy of graft by nano-magnetic ablating particles10.1038/s41598-021-86291-22045-2322https://doaj.org/article/ab892eb9a67d43f2b7d74863b5c1f43e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86291-2https://doaj.org/toc/2045-2322Abstract Artificial vascular treatment is an emerging interdisciplinary subject of medicine. Although the use of artificial vessels has led to many successful advancements, blood clotting remains a major challenge, especially in terms of mural clots created along the vessel wall that do not completely block the vessel. The main objective of this study is to present a method for declotting artificial vessels. This research introduces a novel thrombectomy technique in artificial vessels by employing nano-magnetic particles under a rotating magnetic field to remove mural clots in artificial vessels. A mathematical model describes the relationship between process parameters. In vitro tests confirm the feasibility of nano-magnetic thrombectomy in cleaning and declotting artificial vessels. The results show that the clot fragments are nano-sized, which eliminates the risk of distal emboli as a concern of using current atherectomy techniques. Meanwhile, no damage to the artificial vessels is observed. The results show that the frequency of rotating the magnetic field has the greatest effect on clot removal. The conceptual principles stated in this study also have the potential to be used in other vascular depositions, such as the accumulation of lipids, and calcification atherosclerosis.Abbas MoghanizadehFakhreddin AshrafizadehJaleh VarshosazMahshid KharazihaAntoine FerreiraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Abbas Moghanizadeh Fakhreddin Ashrafizadeh Jaleh Varshosaz Mahshid Kharaziha Antoine Ferreira Noninvasive thrombectomy of graft by nano-magnetic ablating particles
description	Abstract Artificial vascular treatment is an emerging interdisciplinary subject of medicine. Although the use of artificial vessels has led to many successful advancements, blood clotting remains a major challenge, especially in terms of mural clots created along the vessel wall that do not completely block the vessel. The main objective of this study is to present a method for declotting artificial vessels. This research introduces a novel thrombectomy technique in artificial vessels by employing nano-magnetic particles under a rotating magnetic field to remove mural clots in artificial vessels. A mathematical model describes the relationship between process parameters. In vitro tests confirm the feasibility of nano-magnetic thrombectomy in cleaning and declotting artificial vessels. The results show that the clot fragments are nano-sized, which eliminates the risk of distal emboli as a concern of using current atherectomy techniques. Meanwhile, no damage to the artificial vessels is observed. The results show that the frequency of rotating the magnetic field has the greatest effect on clot removal. The conceptual principles stated in this study also have the potential to be used in other vascular depositions, such as the accumulation of lipids, and calcification atherosclerosis.
format	article
author	Abbas Moghanizadeh Fakhreddin Ashrafizadeh Jaleh Varshosaz Mahshid Kharaziha Antoine Ferreira
author_facet	Abbas Moghanizadeh Fakhreddin Ashrafizadeh Jaleh Varshosaz Mahshid Kharaziha Antoine Ferreira
author_sort	Abbas Moghanizadeh
title	Noninvasive thrombectomy of graft by nano-magnetic ablating particles
title_short	Noninvasive thrombectomy of graft by nano-magnetic ablating particles
title_full	Noninvasive thrombectomy of graft by nano-magnetic ablating particles
title_fullStr	Noninvasive thrombectomy of graft by nano-magnetic ablating particles
title_full_unstemmed	Noninvasive thrombectomy of graft by nano-magnetic ablating particles
title_sort	noninvasive thrombectomy of graft by nano-magnetic ablating particles
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ab892eb9a67d43f2b7d74863b5c1f43e
work_keys_str_mv	AT abbasmoghanizadeh noninvasivethrombectomyofgraftbynanomagneticablatingparticles AT fakhreddinashrafizadeh noninvasivethrombectomyofgraftbynanomagneticablatingparticles AT jalehvarshosaz noninvasivethrombectomyofgraftbynanomagneticablatingparticles AT mahshidkharaziha noninvasivethrombectomyofgraftbynanomagneticablatingparticles AT antoineferreira noninvasivethrombectomyofgraftbynanomagneticablatingparticles
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Noninvasive thrombectomy of graft by nano-magnetic ablating particles

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