Major histocompatibility complex in Osteichthyes

Based on analysis of available genome sequences, five gene lineages of MHC class I molecules (MHC I-U, -Z, -S, -L and -P) and one gene lineage of MHC class II molecules (MHC II-D) have been identified in Osteichthyes. In the latter lineage, three MHC II molecule sublineages have been identified (MHC...

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Autores principales:	Stosik Michał, Tokarz-Deptuła Beata, Deptuła Wiesław
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2020
Materias:	osteichthyes major histocompatibility complex Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/ab892f51e2274ec890b96bd773726180
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spelling	oai:doaj.org-article:ab892f51e2274ec890b96bd7737261802021-12-05T14:11:08ZMajor histocompatibility complex in Osteichthyes2450-860810.2478/jvetres-2020-0025https://doaj.org/article/ab892f51e2274ec890b96bd7737261802020-03-01T00:00:00Zhttps://doi.org/10.2478/jvetres-2020-0025https://doaj.org/toc/2450-8608Based on analysis of available genome sequences, five gene lineages of MHC class I molecules (MHC I-U, -Z, -S, -L and -P) and one gene lineage of MHC class II molecules (MHC II-D) have been identified in Osteichthyes. In the latter lineage, three MHC II molecule sublineages have been identified (MHC II-A, -B and -E). As regards MHC class I molecules in Osteichthyes, it is important to take note of the fact that the lineages U and Z in MHC I genes have been identified in almost all fish species examined so far. Phylogenetic studies into MHC II molecule genes of sublineages A and B suggest that they may be descended from the genes of the sublineage named A/B that have been identified in spotted gar (Lepisosteus oculatus). The sublineage E genes of MHC II molecules, which represent the group of non-polymorphic genes with poor expression in the tissues connected with the immune system, are present in primitive fish, i.e. in paddlefish, sturgeons and spotted gar (Lepisosteus oculatus), as well as in cyprinids (Cyprinidae), Atlantic salmon (Salmo salar), and rainbow trout (Oncorhynchus mykiss). Full elucidation of the details relating to the organisation and functioning of the particular components of the major histocompatibility complex in Osteichthyes can advance the understanding of the evolution of the MHC molecule genes and the immune mechanism.Stosik MichałTokarz-Deptuła BeataDeptuła WiesławSciendoarticleosteichthyesmajor histocompatibility complexVeterinary medicineSF600-1100ENJournal of Veterinary Research, Vol 64, Iss 1, Pp 127-136 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	osteichthyes major histocompatibility complex Veterinary medicine SF600-1100
spellingShingle	osteichthyes major histocompatibility complex Veterinary medicine SF600-1100 Stosik Michał Tokarz-Deptuła Beata Deptuła Wiesław Major histocompatibility complex in Osteichthyes
description	Based on analysis of available genome sequences, five gene lineages of MHC class I molecules (MHC I-U, -Z, -S, -L and -P) and one gene lineage of MHC class II molecules (MHC II-D) have been identified in Osteichthyes. In the latter lineage, three MHC II molecule sublineages have been identified (MHC II-A, -B and -E). As regards MHC class I molecules in Osteichthyes, it is important to take note of the fact that the lineages U and Z in MHC I genes have been identified in almost all fish species examined so far. Phylogenetic studies into MHC II molecule genes of sublineages A and B suggest that they may be descended from the genes of the sublineage named A/B that have been identified in spotted gar (Lepisosteus oculatus). The sublineage E genes of MHC II molecules, which represent the group of non-polymorphic genes with poor expression in the tissues connected with the immune system, are present in primitive fish, i.e. in paddlefish, sturgeons and spotted gar (Lepisosteus oculatus), as well as in cyprinids (Cyprinidae), Atlantic salmon (Salmo salar), and rainbow trout (Oncorhynchus mykiss). Full elucidation of the details relating to the organisation and functioning of the particular components of the major histocompatibility complex in Osteichthyes can advance the understanding of the evolution of the MHC molecule genes and the immune mechanism.
format	article
author	Stosik Michał Tokarz-Deptuła Beata Deptuła Wiesław
author_facet	Stosik Michał Tokarz-Deptuła Beata Deptuła Wiesław
author_sort	Stosik Michał
title	Major histocompatibility complex in Osteichthyes
title_short	Major histocompatibility complex in Osteichthyes
title_full	Major histocompatibility complex in Osteichthyes
title_fullStr	Major histocompatibility complex in Osteichthyes
title_full_unstemmed	Major histocompatibility complex in Osteichthyes
title_sort	major histocompatibility complex in osteichthyes
publisher	Sciendo
publishDate	2020
url	https://doaj.org/article/ab892f51e2274ec890b96bd773726180
work_keys_str_mv	AT stosikmichał majorhistocompatibilitycomplexinosteichthyes AT tokarzdeptułabeata majorhistocompatibilitycomplexinosteichthyes AT deptuławiesław majorhistocompatibilitycomplexinosteichthyes
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Major histocompatibility complex in Osteichthyes

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