Etv6 activates vegfa expression through positive and negative transcriptional regulatory networks in Xenopus embryos

How vegfa expression is transcriptionally regulated in vivo is unclear. Here, the authors demonstrate that the ETS transcription factor Etv6 acts as a repressor and an activator of two direct regulators of vegfa expression (foxo3 and klf4, respectively) to control blood formation in Xenopus.

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Autores principales:	Lei Li, Rossella Rispoli, Roger Patient, Aldo Ciau-Uitz, Catherine Porcher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ab8a78cea7274decb08b67fe512c423d
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spelling	oai:doaj.org-article:ab8a78cea7274decb08b67fe512c423d2021-12-02T17:01:52ZEtv6 activates vegfa expression through positive and negative transcriptional regulatory networks in Xenopus embryos10.1038/s41467-019-09050-y2041-1723https://doaj.org/article/ab8a78cea7274decb08b67fe512c423d2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09050-yhttps://doaj.org/toc/2041-1723How vegfa expression is transcriptionally regulated in vivo is unclear. Here, the authors demonstrate that the ETS transcription factor Etv6 acts as a repressor and an activator of two direct regulators of vegfa expression (foxo3 and klf4, respectively) to control blood formation in Xenopus.Lei LiRossella RispoliRoger PatientAldo Ciau-UitzCatherine PorcherNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lei Li Rossella Rispoli Roger Patient Aldo Ciau-Uitz Catherine Porcher Etv6 activates vegfa expression through positive and negative transcriptional regulatory networks in Xenopus embryos
description	How vegfa expression is transcriptionally regulated in vivo is unclear. Here, the authors demonstrate that the ETS transcription factor Etv6 acts as a repressor and an activator of two direct regulators of vegfa expression (foxo3 and klf4, respectively) to control blood formation in Xenopus.
format	article
author	Lei Li Rossella Rispoli Roger Patient Aldo Ciau-Uitz Catherine Porcher
author_facet	Lei Li Rossella Rispoli Roger Patient Aldo Ciau-Uitz Catherine Porcher
author_sort	Lei Li
title	Etv6 activates vegfa expression through positive and negative transcriptional regulatory networks in Xenopus embryos
title_short	Etv6 activates vegfa expression through positive and negative transcriptional regulatory networks in Xenopus embryos
title_full	Etv6 activates vegfa expression through positive and negative transcriptional regulatory networks in Xenopus embryos
title_fullStr	Etv6 activates vegfa expression through positive and negative transcriptional regulatory networks in Xenopus embryos
title_full_unstemmed	Etv6 activates vegfa expression through positive and negative transcriptional regulatory networks in Xenopus embryos
title_sort	etv6 activates vegfa expression through positive and negative transcriptional regulatory networks in xenopus embryos
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ab8a78cea7274decb08b67fe512c423d
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Etv6 activates vegfa expression through positive and negative transcriptional regulatory networks in Xenopus embryos

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