Etv6 activates vegfa expression through positive and negative transcriptional regulatory networks in Xenopus embryos

How vegfa expression is transcriptionally regulated in vivo is unclear. Here, the authors demonstrate that the ETS transcription factor Etv6 acts as a repressor and an activator of two direct regulators of vegfa expression (foxo3 and klf4, respectively) to control blood formation in Xenopus.

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Autores principales: Lei Li, Rossella Rispoli, Roger Patient, Aldo Ciau-Uitz, Catherine Porcher
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/ab8a78cea7274decb08b67fe512c423d
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