The influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis

Abstract As interest in space exploration rises, there is a growing need to quantify the impact of microgravity on the growth, survival, and adaptation of microorganisms, including those responsible for astronaut illness. Motility is a key microbial behavior that plays important roles in nutrient as...

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Autores principales:	Jacqueline M. Acres, Myka Jaap Youngapelian, Jay Nadeau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biotechnology TP248.13-248.65 Physiology QP1-981
Acceso en línea:	https://doaj.org/article/ab8e96e5c9f145329132f9f5637eeb2e
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spelling	oai:doaj.org-article:ab8e96e5c9f145329132f9f5637eeb2e2021-12-02T16:23:21ZThe influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis10.1038/s41526-021-00135-x2373-8065https://doaj.org/article/ab8e96e5c9f145329132f9f5637eeb2e2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41526-021-00135-xhttps://doaj.org/toc/2373-8065Abstract As interest in space exploration rises, there is a growing need to quantify the impact of microgravity on the growth, survival, and adaptation of microorganisms, including those responsible for astronaut illness. Motility is a key microbial behavior that plays important roles in nutrient assimilation, tissue localization and invasion, pathogenicity, biofilm formation, and ultimately survival. Very few studies have specifically looked at the effects of microgravity on the phenotypes of microbial motility. However, genomic and transcriptomic studies give a broad general picture of overall gene expression that can be used to predict motility phenotypes based upon selected genes, such as those responsible for flagellar synthesis and function and/or taxis. In this review, we focus on specific strains of Gram-negative bacteria that have been the most studied in this context. We begin with a discussion of Earth-based microgravity simulation systems and how they may affect the genes and phenotypes of interest. We then summarize results from both Earth- and space-based systems showing effects of microgravity on motility-related genes and phenotypes.Jacqueline M. AcresMyka Jaap YoungapelianJay NadeauNature PortfolioarticleBiotechnologyTP248.13-248.65PhysiologyQP1-981ENnpj Microgravity, Vol 7, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biotechnology TP248.13-248.65 Physiology QP1-981
spellingShingle	Biotechnology TP248.13-248.65 Physiology QP1-981 Jacqueline M. Acres Myka Jaap Youngapelian Jay Nadeau The influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis
description	Abstract As interest in space exploration rises, there is a growing need to quantify the impact of microgravity on the growth, survival, and adaptation of microorganisms, including those responsible for astronaut illness. Motility is a key microbial behavior that plays important roles in nutrient assimilation, tissue localization and invasion, pathogenicity, biofilm formation, and ultimately survival. Very few studies have specifically looked at the effects of microgravity on the phenotypes of microbial motility. However, genomic and transcriptomic studies give a broad general picture of overall gene expression that can be used to predict motility phenotypes based upon selected genes, such as those responsible for flagellar synthesis and function and/or taxis. In this review, we focus on specific strains of Gram-negative bacteria that have been the most studied in this context. We begin with a discussion of Earth-based microgravity simulation systems and how they may affect the genes and phenotypes of interest. We then summarize results from both Earth- and space-based systems showing effects of microgravity on motility-related genes and phenotypes.
format	article
author	Jacqueline M. Acres Myka Jaap Youngapelian Jay Nadeau
author_facet	Jacqueline M. Acres Myka Jaap Youngapelian Jay Nadeau
author_sort	Jacqueline M. Acres
title	The influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis
title_short	The influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis
title_full	The influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis
title_fullStr	The influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis
title_full_unstemmed	The influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis
title_sort	influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ab8e96e5c9f145329132f9f5637eeb2e
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The influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis

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