Quantitative perfusion imaging of neoplastic liver lesions: A multi-institution study

Abstract We describe multi-institutional experience using free-breathing, 3D Spiral GRAPPA-based quantitative perfusion MRI in characterizing neoplastic liver masses. 45 patients (age: 48–72 years) were prospectively recruited at University Hospitals, Cleveland, USA on a 3 Tesla (T) MRI, and at Zhon...

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Autores principales:	Shivani Pahwa, Hao Liu, Yong Chen, Sara Dastmalchian, Gregory O’Connor, Ziang Lu, Chaitra Badve, Alice Yu, Katherine Wright, Hamid Chalian, Shengxiang Rao, Caixia Fu, Ignacio Vallines, Mark Griswold, Nicole Seiberlich, Mengsu Zeng, Vikas Gulani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ab8f6f64ea0d469b985ed74fab602778
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spelling	oai:doaj.org-article:ab8f6f64ea0d469b985ed74fab6027782021-12-02T15:09:10ZQuantitative perfusion imaging of neoplastic liver lesions: A multi-institution study10.1038/s41598-018-20726-12045-2322https://doaj.org/article/ab8f6f64ea0d469b985ed74fab6027782018-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-20726-1https://doaj.org/toc/2045-2322Abstract We describe multi-institutional experience using free-breathing, 3D Spiral GRAPPA-based quantitative perfusion MRI in characterizing neoplastic liver masses. 45 patients (age: 48–72 years) were prospectively recruited at University Hospitals, Cleveland, USA on a 3 Tesla (T) MRI, and at Zhongshan Hospital, Shanghai, China on a 1.5 T MRI. Contrast-enhanced volumetric T1-weighted images were acquired and a dual-input single-compartment model used to derive arterial fraction (AF), distribution volume (DV) and mean transit time (MTT) for the lesions and normal parenchyma. The measurements were compared using two-tailed Student’s t-test, with Bonferroni correction applied for multiple-comparison testing. 28 hepatocellular carcinoma (HCC) and 17 metastatic lesions were evaluated. No significant difference was noted in perfusion parameters of normal liver parenchyma and neoplastic masses at two centers (p = 0.62 for AF, 0.015 for DV, 0.42 for MTT for HCC, p = 0.13 for AF, 0.97 for DV, 0.78 for MTT for metastases). There was statistically significant difference in AF, DV, and MTT of metastases and AF and DV of HCC compared to normal liver parenchyma (p < 0.5/9 = 0.0055). A statistically significant difference was noted in the MTT of metastases compared to hepatocellular carcinoma (p < 0.001*10-5). In conclusion, 3D Spiral-GRAPPA enabled quantitative free-breathing perfusion MRI exam provides robust perfusion parameters.Shivani PahwaHao LiuYong ChenSara DastmalchianGregory O’ConnorZiang LuChaitra BadveAlice YuKatherine WrightHamid ChalianShengxiang RaoCaixia FuIgnacio VallinesMark GriswoldNicole SeiberlichMengsu ZengVikas GulaniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shivani Pahwa Hao Liu Yong Chen Sara Dastmalchian Gregory O’Connor Ziang Lu Chaitra Badve Alice Yu Katherine Wright Hamid Chalian Shengxiang Rao Caixia Fu Ignacio Vallines Mark Griswold Nicole Seiberlich Mengsu Zeng Vikas Gulani Quantitative perfusion imaging of neoplastic liver lesions: A multi-institution study
description	Abstract We describe multi-institutional experience using free-breathing, 3D Spiral GRAPPA-based quantitative perfusion MRI in characterizing neoplastic liver masses. 45 patients (age: 48–72 years) were prospectively recruited at University Hospitals, Cleveland, USA on a 3 Tesla (T) MRI, and at Zhongshan Hospital, Shanghai, China on a 1.5 T MRI. Contrast-enhanced volumetric T1-weighted images were acquired and a dual-input single-compartment model used to derive arterial fraction (AF), distribution volume (DV) and mean transit time (MTT) for the lesions and normal parenchyma. The measurements were compared using two-tailed Student’s t-test, with Bonferroni correction applied for multiple-comparison testing. 28 hepatocellular carcinoma (HCC) and 17 metastatic lesions were evaluated. No significant difference was noted in perfusion parameters of normal liver parenchyma and neoplastic masses at two centers (p = 0.62 for AF, 0.015 for DV, 0.42 for MTT for HCC, p = 0.13 for AF, 0.97 for DV, 0.78 for MTT for metastases). There was statistically significant difference in AF, DV, and MTT of metastases and AF and DV of HCC compared to normal liver parenchyma (p < 0.5/9 = 0.0055). A statistically significant difference was noted in the MTT of metastases compared to hepatocellular carcinoma (p < 0.001*10-5). In conclusion, 3D Spiral-GRAPPA enabled quantitative free-breathing perfusion MRI exam provides robust perfusion parameters.
format	article
author	Shivani Pahwa Hao Liu Yong Chen Sara Dastmalchian Gregory O’Connor Ziang Lu Chaitra Badve Alice Yu Katherine Wright Hamid Chalian Shengxiang Rao Caixia Fu Ignacio Vallines Mark Griswold Nicole Seiberlich Mengsu Zeng Vikas Gulani
author_facet	Shivani Pahwa Hao Liu Yong Chen Sara Dastmalchian Gregory O’Connor Ziang Lu Chaitra Badve Alice Yu Katherine Wright Hamid Chalian Shengxiang Rao Caixia Fu Ignacio Vallines Mark Griswold Nicole Seiberlich Mengsu Zeng Vikas Gulani
author_sort	Shivani Pahwa
title	Quantitative perfusion imaging of neoplastic liver lesions: A multi-institution study
title_short	Quantitative perfusion imaging of neoplastic liver lesions: A multi-institution study
title_full	Quantitative perfusion imaging of neoplastic liver lesions: A multi-institution study
title_fullStr	Quantitative perfusion imaging of neoplastic liver lesions: A multi-institution study
title_full_unstemmed	Quantitative perfusion imaging of neoplastic liver lesions: A multi-institution study
title_sort	quantitative perfusion imaging of neoplastic liver lesions: a multi-institution study
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ab8f6f64ea0d469b985ed74fab602778
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Quantitative perfusion imaging of neoplastic liver lesions: A multi-institution study

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