Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent

Humans that reach high altitude soon after the first ascent show faster adaptation to hypoxia. Songet al. show that this adaptive response relies on decreased red blood cell uptake of plasma adenosine due to reduced levels of nucleoside transporter ENT1 resulting from coordinated adenosine generatio...

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Autores principales:	Anren Song, Yujin Zhang, Leng Han, Gennady G. Yegutkin, Hong Liu, Kaiqi Sun, Angelo D’Alessandro, Jessica Li, Harry Karmouty-Quintana, Takayuki Iriyama, Tingting Weng, Shushan Zhao, Wei Wang, Hongyu Wu, Travis Nemkov, Andrew W. Subudhi, Sonja Jameson-Van Houten, Colleen G. Julian, Andrew T. Lovering, Kirk C. Hansen, Hong Zhang, Mikhail Bogdanov, William Dowhan, Jianping Jin, Rodney E. Kellems, Holger K. Eltzschig, Michael Blackburn, Robert C. Roach, Yang Xia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ab90ef4532bf424aa26dc070a2adc9be
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spelling	oai:doaj.org-article:ab90ef4532bf424aa26dc070a2adc9be2021-12-02T17:06:19ZErythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent10.1038/ncomms141082041-1723https://doaj.org/article/ab90ef4532bf424aa26dc070a2adc9be2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14108https://doaj.org/toc/2041-1723Humans that reach high altitude soon after the first ascent show faster adaptation to hypoxia. Songet al. show that this adaptive response relies on decreased red blood cell uptake of plasma adenosine due to reduced levels of nucleoside transporter ENT1 resulting from coordinated adenosine generation by ectonucleotidase CD73 and activation of A2B receptors.Anren SongYujin ZhangLeng HanGennady G. YegutkinHong LiuKaiqi SunAngelo D’AlessandroJessica LiHarry Karmouty-QuintanaTakayuki IriyamaTingting WengShushan ZhaoWei WangHongyu WuTravis NemkovAndrew W. SubudhiSonja Jameson-Van HoutenColleen G. JulianAndrew T. LoveringKirk C. HansenHong ZhangMikhail BogdanovWilliam DowhanJianping JinRodney E. KellemsHolger K. EltzschigMichael BlackburnRobert C. RoachYang XiaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anren Song Yujin Zhang Leng Han Gennady G. Yegutkin Hong Liu Kaiqi Sun Angelo D’Alessandro Jessica Li Harry Karmouty-Quintana Takayuki Iriyama Tingting Weng Shushan Zhao Wei Wang Hongyu Wu Travis Nemkov Andrew W. Subudhi Sonja Jameson-Van Houten Colleen G. Julian Andrew T. Lovering Kirk C. Hansen Hong Zhang Mikhail Bogdanov William Dowhan Jianping Jin Rodney E. Kellems Holger K. Eltzschig Michael Blackburn Robert C. Roach Yang Xia Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent
description	Humans that reach high altitude soon after the first ascent show faster adaptation to hypoxia. Songet al. show that this adaptive response relies on decreased red blood cell uptake of plasma adenosine due to reduced levels of nucleoside transporter ENT1 resulting from coordinated adenosine generation by ectonucleotidase CD73 and activation of A2B receptors.
format	article
author	Anren Song Yujin Zhang Leng Han Gennady G. Yegutkin Hong Liu Kaiqi Sun Angelo D’Alessandro Jessica Li Harry Karmouty-Quintana Takayuki Iriyama Tingting Weng Shushan Zhao Wei Wang Hongyu Wu Travis Nemkov Andrew W. Subudhi Sonja Jameson-Van Houten Colleen G. Julian Andrew T. Lovering Kirk C. Hansen Hong Zhang Mikhail Bogdanov William Dowhan Jianping Jin Rodney E. Kellems Holger K. Eltzschig Michael Blackburn Robert C. Roach Yang Xia
author_facet	Anren Song Yujin Zhang Leng Han Gennady G. Yegutkin Hong Liu Kaiqi Sun Angelo D’Alessandro Jessica Li Harry Karmouty-Quintana Takayuki Iriyama Tingting Weng Shushan Zhao Wei Wang Hongyu Wu Travis Nemkov Andrew W. Subudhi Sonja Jameson-Van Houten Colleen G. Julian Andrew T. Lovering Kirk C. Hansen Hong Zhang Mikhail Bogdanov William Dowhan Jianping Jin Rodney E. Kellems Holger K. Eltzschig Michael Blackburn Robert C. Roach Yang Xia
author_sort	Anren Song
title	Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent
title_short	Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent
title_full	Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent
title_fullStr	Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent
title_full_unstemmed	Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent
title_sort	erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ab90ef4532bf424aa26dc070a2adc9be
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Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent

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