CREB mediates the C. elegans dauer polyphenism through direct and cell-autonomous regulation of TGF-β expression.

Animals can adapt to dynamic environmental conditions by modulating their developmental programs. Understanding the genetic architecture and molecular mechanisms underlying developmental plasticity in response to changing environments is an important and emerging area of research. Here, we show a no...

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Autores principales:	JiSoo Park, Hyekyoung Oh, Do-Young Kim, YongJin Cheon, Yeon-Ji Park, Hyeonjeong Hwang, Scott J Neal, Abdul Rouf Dar, Rebecca A Butcher, Piali Sengupta, Dae-Won Kim, Kyuhyung Kim
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/ab94ee1c1b4a455fa7c93a412714ed8a
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spelling	oai:doaj.org-article:ab94ee1c1b4a455fa7c93a412714ed8a2021-12-02T20:02:56ZCREB mediates the C. elegans dauer polyphenism through direct and cell-autonomous regulation of TGF-β expression.1553-73901553-740410.1371/journal.pgen.1009678https://doaj.org/article/ab94ee1c1b4a455fa7c93a412714ed8a2021-07-01T00:00:00Zhttps://doi.org/10.1371/journal.pgen.1009678https://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404Animals can adapt to dynamic environmental conditions by modulating their developmental programs. Understanding the genetic architecture and molecular mechanisms underlying developmental plasticity in response to changing environments is an important and emerging area of research. Here, we show a novel role of cAMP response element binding protein (CREB)-encoding crh-1 gene in developmental polyphenism of C. elegans. Under conditions that promote normal development in wild-type animals, crh-1 mutants inappropriately form transient pre-dauer (L2d) larvae and express the L2d marker gene. L2d formation in crh-1 mutants is specifically induced by the ascaroside pheromone ascr#5 (asc-ωC3; C3), and crh-1 functions autonomously in the ascr#5-sensing ASI neurons to inhibit L2d formation. Moreover, we find that CRH-1 directly binds upstream of the daf-7 TGF-β locus and promotes its expression in the ASI neurons. Taken together, these results provide new insight into how animals alter their developmental programs in response to environmental changes.JiSoo ParkHyekyoung OhDo-Young KimYongJin CheonYeon-Ji ParkHyeonjeong HwangScott J NealAbdul Rouf DarRebecca A ButcherPiali SenguptaDae-Won KimKyuhyung KimPublic Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 17, Iss 7, p e1009678 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 JiSoo Park Hyekyoung Oh Do-Young Kim YongJin Cheon Yeon-Ji Park Hyeonjeong Hwang Scott J Neal Abdul Rouf Dar Rebecca A Butcher Piali Sengupta Dae-Won Kim Kyuhyung Kim CREB mediates the C. elegans dauer polyphenism through direct and cell-autonomous regulation of TGF-β expression.
description	Animals can adapt to dynamic environmental conditions by modulating their developmental programs. Understanding the genetic architecture and molecular mechanisms underlying developmental plasticity in response to changing environments is an important and emerging area of research. Here, we show a novel role of cAMP response element binding protein (CREB)-encoding crh-1 gene in developmental polyphenism of C. elegans. Under conditions that promote normal development in wild-type animals, crh-1 mutants inappropriately form transient pre-dauer (L2d) larvae and express the L2d marker gene. L2d formation in crh-1 mutants is specifically induced by the ascaroside pheromone ascr#5 (asc-ωC3; C3), and crh-1 functions autonomously in the ascr#5-sensing ASI neurons to inhibit L2d formation. Moreover, we find that CRH-1 directly binds upstream of the daf-7 TGF-β locus and promotes its expression in the ASI neurons. Taken together, these results provide new insight into how animals alter their developmental programs in response to environmental changes.
format	article
author	JiSoo Park Hyekyoung Oh Do-Young Kim YongJin Cheon Yeon-Ji Park Hyeonjeong Hwang Scott J Neal Abdul Rouf Dar Rebecca A Butcher Piali Sengupta Dae-Won Kim Kyuhyung Kim
author_facet	JiSoo Park Hyekyoung Oh Do-Young Kim YongJin Cheon Yeon-Ji Park Hyeonjeong Hwang Scott J Neal Abdul Rouf Dar Rebecca A Butcher Piali Sengupta Dae-Won Kim Kyuhyung Kim
author_sort	JiSoo Park
title	CREB mediates the C. elegans dauer polyphenism through direct and cell-autonomous regulation of TGF-β expression.
title_short	CREB mediates the C. elegans dauer polyphenism through direct and cell-autonomous regulation of TGF-β expression.
title_full	CREB mediates the C. elegans dauer polyphenism through direct and cell-autonomous regulation of TGF-β expression.
title_fullStr	CREB mediates the C. elegans dauer polyphenism through direct and cell-autonomous regulation of TGF-β expression.
title_full_unstemmed	CREB mediates the C. elegans dauer polyphenism through direct and cell-autonomous regulation of TGF-β expression.
title_sort	creb mediates the c. elegans dauer polyphenism through direct and cell-autonomous regulation of tgf-β expression.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/ab94ee1c1b4a455fa7c93a412714ed8a
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CREB mediates the C. elegans dauer polyphenism through direct and cell-autonomous regulation of TGF-β expression.

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