A dopaminergic switch for fear to safety transitions

Fear memories are overcome only when it is ascertained that fearful responses are not appropriate. Here the authors demonstrate that activity in dopamine neurons is necessary to extinguish fear responses and two distinct dopamine neuron projections exert opposing effects on extinction learning.

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Autores principales:	Ray Luo, Akira Uematsu, Adam Weitemier, Luca Aquili, Jenny Koivumaa, Thomas J. McHugh, Joshua P. Johansen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ab9559fb1bd242d5b4772bf9b61f7537
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spelling	oai:doaj.org-article:ab9559fb1bd242d5b4772bf9b61f75372021-12-02T16:49:38ZA dopaminergic switch for fear to safety transitions10.1038/s41467-018-04784-72041-1723https://doaj.org/article/ab9559fb1bd242d5b4772bf9b61f75372018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04784-7https://doaj.org/toc/2041-1723Fear memories are overcome only when it is ascertained that fearful responses are not appropriate. Here the authors demonstrate that activity in dopamine neurons is necessary to extinguish fear responses and two distinct dopamine neuron projections exert opposing effects on extinction learning.Ray LuoAkira UematsuAdam WeitemierLuca AquiliJenny KoivumaaThomas J. McHughJoshua P. JohansenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ray Luo Akira Uematsu Adam Weitemier Luca Aquili Jenny Koivumaa Thomas J. McHugh Joshua P. Johansen A dopaminergic switch for fear to safety transitions
description	Fear memories are overcome only when it is ascertained that fearful responses are not appropriate. Here the authors demonstrate that activity in dopamine neurons is necessary to extinguish fear responses and two distinct dopamine neuron projections exert opposing effects on extinction learning.
format	article
author	Ray Luo Akira Uematsu Adam Weitemier Luca Aquili Jenny Koivumaa Thomas J. McHugh Joshua P. Johansen
author_facet	Ray Luo Akira Uematsu Adam Weitemier Luca Aquili Jenny Koivumaa Thomas J. McHugh Joshua P. Johansen
author_sort	Ray Luo
title	A dopaminergic switch for fear to safety transitions
title_short	A dopaminergic switch for fear to safety transitions
title_full	A dopaminergic switch for fear to safety transitions
title_fullStr	A dopaminergic switch for fear to safety transitions
title_full_unstemmed	A dopaminergic switch for fear to safety transitions
title_sort	dopaminergic switch for fear to safety transitions
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ab9559fb1bd242d5b4772bf9b61f7537
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A dopaminergic switch for fear to safety transitions

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