Modelling physiology of haemodynamic adaptation in short-term microgravity exposure and orthostatic stress on Earth

Abstract Cardiovascular haemodynamics alters during posture changes and exposure to microgravity. Vascular auto-remodelling observed in subjects living in space environment causes them orthostatic intolerance when they return on Earth. In this study we modelled the human haemodynamics with focus on...

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Autores principales:	Parvin Mohammadyari, Giacomo Gadda, Angelo Taibi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ab95b19a847149359319961c7a284851
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spelling	oai:doaj.org-article:ab95b19a847149359319961c7a2848512021-12-02T13:34:51ZModelling physiology of haemodynamic adaptation in short-term microgravity exposure and orthostatic stress on Earth10.1038/s41598-021-84197-72045-2322https://doaj.org/article/ab95b19a847149359319961c7a2848512021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84197-7https://doaj.org/toc/2045-2322Abstract Cardiovascular haemodynamics alters during posture changes and exposure to microgravity. Vascular auto-remodelling observed in subjects living in space environment causes them orthostatic intolerance when they return on Earth. In this study we modelled the human haemodynamics with focus on head and neck exposed to different hydrostatic pressures in supine, upright (head-up tilt), head-down tilt position, and microgravity environment by using a well-developed 1D-0D haemodynamic model. The model consists of two parts that simulates the arterial (1D) and brain-venous (0D) vascular tree. The cardiovascular system is built as a network of hydraulic resistances and capacitances to properly model physiological parameters like total peripheral resistance, and to calculate vascular pressure and the related flow rate at any branch of the tree. The model calculated 30.0 mmHg (30%), 7.1 mmHg (78%), 1.7 mmHg (38%) reduction in mean blood pressure, intracranial pressure and central venous pressure after posture change from supine to upright, respectively. The modelled brain drainage outflow percentage from internal jugular veins is 67% and 26% for supine and upright posture, while for head-down tilt and microgravity is 65% and 72%, respectively. The model confirmed the role of peripheral veins in regional blood redistribution during posture change from supine to upright and microgravity environment as hypothesized in literature. The model is able to reproduce the known haemodynamic effects of hydraulic pressure change and weightlessness. It also provides a virtual laboratory to examine the consequence of a wide range of orthostatic stresses on human haemodynamics.Parvin MohammadyariGiacomo GaddaAngelo TaibiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Parvin Mohammadyari Giacomo Gadda Angelo Taibi Modelling physiology of haemodynamic adaptation in short-term microgravity exposure and orthostatic stress on Earth
description	Abstract Cardiovascular haemodynamics alters during posture changes and exposure to microgravity. Vascular auto-remodelling observed in subjects living in space environment causes them orthostatic intolerance when they return on Earth. In this study we modelled the human haemodynamics with focus on head and neck exposed to different hydrostatic pressures in supine, upright (head-up tilt), head-down tilt position, and microgravity environment by using a well-developed 1D-0D haemodynamic model. The model consists of two parts that simulates the arterial (1D) and brain-venous (0D) vascular tree. The cardiovascular system is built as a network of hydraulic resistances and capacitances to properly model physiological parameters like total peripheral resistance, and to calculate vascular pressure and the related flow rate at any branch of the tree. The model calculated 30.0 mmHg (30%), 7.1 mmHg (78%), 1.7 mmHg (38%) reduction in mean blood pressure, intracranial pressure and central venous pressure after posture change from supine to upright, respectively. The modelled brain drainage outflow percentage from internal jugular veins is 67% and 26% for supine and upright posture, while for head-down tilt and microgravity is 65% and 72%, respectively. The model confirmed the role of peripheral veins in regional blood redistribution during posture change from supine to upright and microgravity environment as hypothesized in literature. The model is able to reproduce the known haemodynamic effects of hydraulic pressure change and weightlessness. It also provides a virtual laboratory to examine the consequence of a wide range of orthostatic stresses on human haemodynamics.
format	article
author	Parvin Mohammadyari Giacomo Gadda Angelo Taibi
author_facet	Parvin Mohammadyari Giacomo Gadda Angelo Taibi
author_sort	Parvin Mohammadyari
title	Modelling physiology of haemodynamic adaptation in short-term microgravity exposure and orthostatic stress on Earth
title_short	Modelling physiology of haemodynamic adaptation in short-term microgravity exposure and orthostatic stress on Earth
title_full	Modelling physiology of haemodynamic adaptation in short-term microgravity exposure and orthostatic stress on Earth
title_fullStr	Modelling physiology of haemodynamic adaptation in short-term microgravity exposure and orthostatic stress on Earth
title_full_unstemmed	Modelling physiology of haemodynamic adaptation in short-term microgravity exposure and orthostatic stress on Earth
title_sort	modelling physiology of haemodynamic adaptation in short-term microgravity exposure and orthostatic stress on earth
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ab95b19a847149359319961c7a284851
work_keys_str_mv	AT parvinmohammadyari modellingphysiologyofhaemodynamicadaptationinshorttermmicrogravityexposureandorthostaticstressonearth AT giacomogadda modellingphysiologyofhaemodynamicadaptationinshorttermmicrogravityexposureandorthostaticstressonearth AT angelotaibi modellingphysiologyofhaemodynamicadaptationinshorttermmicrogravityexposureandorthostaticstressonearth
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Modelling physiology of haemodynamic adaptation in short-term microgravity exposure and orthostatic stress on Earth

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