Impact of age on the circadian visual system and the sleep-wake cycle in mus musculus

Abstract Age plays a critical role in disease development and tolerance to cancer treatment, often leading to an increased risk of developing negative symptoms including sleep disturbances. Circadian rhythms and sleep become disrupted as organisms age. In this study, we explored the behavioral alter...

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Autores principales:	Dorela D. Shuboni-Mulligan, Demarrius L. Young, Julianie De La Cruz Minyety, Elizabeth Vera, Jeeva Munasinghe, Andrew J. Gall, Mark R. Gilbert, Terri S. Armstrong, DeeDee K. Smart
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/ab97f4d9754f45608961761fc5d40767
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spelling	oai:doaj.org-article:ab97f4d9754f45608961761fc5d407672021-12-02T14:42:57ZImpact of age on the circadian visual system and the sleep-wake cycle in mus musculus10.1038/s41514-021-00063-w2056-3973https://doaj.org/article/ab97f4d9754f45608961761fc5d407672021-05-01T00:00:00Zhttps://doi.org/10.1038/s41514-021-00063-whttps://doaj.org/toc/2056-3973Abstract Age plays a critical role in disease development and tolerance to cancer treatment, often leading to an increased risk of developing negative symptoms including sleep disturbances. Circadian rhythms and sleep become disrupted as organisms age. In this study, we explored the behavioral alterations in sleep, circadian rhythms, and masking using a novel video system and interrogate the long-term impact of age-based changes in the non-image forming visual pathway on brain anatomy. We demonstrated the feasibility and utility of the novel system and establish that older mice have disruptions in sleep, circadian rhythms, and masking behaviors that were associated with major negative volume alterations in the non-imaging forming visual system, critical for the induction and rhythmic expression of sleep. These results provide important insights into a mechanism, showing brain atrophy is linked to age in distinct non-image forming visual regions, which may predispose older individuals to developing circadian and sleep dysfunction when further challenged by disease or treatment.Dorela D. Shuboni-MulliganDemarrius L. YoungJulianie De La Cruz MinyetyElizabeth VeraJeeva MunasingheAndrew J. GallMark R. GilbertTerri S. ArmstrongDeeDee K. SmartNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Dorela D. Shuboni-Mulligan Demarrius L. Young Julianie De La Cruz Minyety Elizabeth Vera Jeeva Munasinghe Andrew J. Gall Mark R. Gilbert Terri S. Armstrong DeeDee K. Smart Impact of age on the circadian visual system and the sleep-wake cycle in mus musculus
description	Abstract Age plays a critical role in disease development and tolerance to cancer treatment, often leading to an increased risk of developing negative symptoms including sleep disturbances. Circadian rhythms and sleep become disrupted as organisms age. In this study, we explored the behavioral alterations in sleep, circadian rhythms, and masking using a novel video system and interrogate the long-term impact of age-based changes in the non-image forming visual pathway on brain anatomy. We demonstrated the feasibility and utility of the novel system and establish that older mice have disruptions in sleep, circadian rhythms, and masking behaviors that were associated with major negative volume alterations in the non-imaging forming visual system, critical for the induction and rhythmic expression of sleep. These results provide important insights into a mechanism, showing brain atrophy is linked to age in distinct non-image forming visual regions, which may predispose older individuals to developing circadian and sleep dysfunction when further challenged by disease or treatment.
format	article
author	Dorela D. Shuboni-Mulligan Demarrius L. Young Julianie De La Cruz Minyety Elizabeth Vera Jeeva Munasinghe Andrew J. Gall Mark R. Gilbert Terri S. Armstrong DeeDee K. Smart
author_facet	Dorela D. Shuboni-Mulligan Demarrius L. Young Julianie De La Cruz Minyety Elizabeth Vera Jeeva Munasinghe Andrew J. Gall Mark R. Gilbert Terri S. Armstrong DeeDee K. Smart
author_sort	Dorela D. Shuboni-Mulligan
title	Impact of age on the circadian visual system and the sleep-wake cycle in mus musculus
title_short	Impact of age on the circadian visual system and the sleep-wake cycle in mus musculus
title_full	Impact of age on the circadian visual system and the sleep-wake cycle in mus musculus
title_fullStr	Impact of age on the circadian visual system and the sleep-wake cycle in mus musculus
title_full_unstemmed	Impact of age on the circadian visual system and the sleep-wake cycle in mus musculus
title_sort	impact of age on the circadian visual system and the sleep-wake cycle in mus musculus
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ab97f4d9754f45608961761fc5d40767
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Impact of age on the circadian visual system and the sleep-wake cycle in mus musculus

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