Distribution bias and biochemical characterization of TOP1MT single nucleotide variants

Distribution bias and biochemical characterization of TOP1MT single nucleotide variants

Abstract Mitochondrial topoisomerase I (TOP1MT) is a type IB topoisomerase encoded in the nucleus of vertebrate cells. In contrast to the other five human topoisomerases, TOP1MT possesses two high frequency single nucleotide variants (SNVs), rs11544484 (V256I, Minor Allele Frequency = 0.27) and rs22...

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Autores principales: Hongliang Zhang, Yeonee Seol, Keli Agama, Keir C. Neuman, Yves Pommier
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/ab9c848683b442378bbba0097b3e7468
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