Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition

A significant proportion of patients develop innate or acquired resistance to immune checkpoint inhibitors. Here, the authors show that resistance to anti-PD-1 blockade is associated with TGF-beta driven major histocompatibility complex I (MHCI) down-regulation and a de-differentiated phenotype in m...

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Autores principales:	Jenny H. Lee, Elena Shklovskaya, Su Yin Lim, Matteo S. Carlino, Alexander M. Menzies, Ashleigh Stewart, Bernadette Pedersen, Malama Irvine, Sara Alavi, Jean Y. H. Yang, Dario Strbenac, Robyn P. M. Saw, John F. Thompson, James S. Wilmott, Richard A. Scolyer, Georgina V. Long, Richard F. Kefford, Helen Rizos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ab9ea89ca686469ba37cbf4ad9951d86
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spelling	oai:doaj.org-article:ab9ea89ca686469ba37cbf4ad9951d862021-12-02T14:41:26ZTranscriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition10.1038/s41467-020-15726-72041-1723https://doaj.org/article/ab9ea89ca686469ba37cbf4ad9951d862020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15726-7https://doaj.org/toc/2041-1723A significant proportion of patients develop innate or acquired resistance to immune checkpoint inhibitors. Here, the authors show that resistance to anti-PD-1 blockade is associated with TGF-beta driven major histocompatibility complex I (MHCI) down-regulation and a de-differentiated phenotype in melanoma patients.Jenny H. LeeElena ShklovskayaSu Yin LimMatteo S. CarlinoAlexander M. MenziesAshleigh StewartBernadette PedersenMalama IrvineSara AlaviJean Y. H. YangDario StrbenacRobyn P. M. SawJohn F. ThompsonJames S. WilmottRichard A. ScolyerGeorgina V. LongRichard F. KeffordHelen RizosNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jenny H. Lee Elena Shklovskaya Su Yin Lim Matteo S. Carlino Alexander M. Menzies Ashleigh Stewart Bernadette Pedersen Malama Irvine Sara Alavi Jean Y. H. Yang Dario Strbenac Robyn P. M. Saw John F. Thompson James S. Wilmott Richard A. Scolyer Georgina V. Long Richard F. Kefford Helen Rizos Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition
description	A significant proportion of patients develop innate or acquired resistance to immune checkpoint inhibitors. Here, the authors show that resistance to anti-PD-1 blockade is associated with TGF-beta driven major histocompatibility complex I (MHCI) down-regulation and a de-differentiated phenotype in melanoma patients.
format	article
author	Jenny H. Lee Elena Shklovskaya Su Yin Lim Matteo S. Carlino Alexander M. Menzies Ashleigh Stewart Bernadette Pedersen Malama Irvine Sara Alavi Jean Y. H. Yang Dario Strbenac Robyn P. M. Saw John F. Thompson James S. Wilmott Richard A. Scolyer Georgina V. Long Richard F. Kefford Helen Rizos
author_facet	Jenny H. Lee Elena Shklovskaya Su Yin Lim Matteo S. Carlino Alexander M. Menzies Ashleigh Stewart Bernadette Pedersen Malama Irvine Sara Alavi Jean Y. H. Yang Dario Strbenac Robyn P. M. Saw John F. Thompson James S. Wilmott Richard A. Scolyer Georgina V. Long Richard F. Kefford Helen Rizos
author_sort	Jenny H. Lee
title	Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition
title_short	Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition
title_full	Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition
title_fullStr	Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition
title_full_unstemmed	Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition
title_sort	transcriptional downregulation of mhc class i and melanoma de- differentiation in resistance to pd-1 inhibition
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ab9ea89ca686469ba37cbf4ad9951d86
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Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition

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