Prognostic significance of p53, Sox11, and Pax5 co-expression in mantle cell lymphoma

Abstract Mantle cell lymphoma (MCL) is a relatively rare subtype of non-Hodgkin’s lymphoma. To identify molecular biomarkers in MCL, we performed immunohistochemistry tissue arrays using biopsies from 64 MCL patients diagnosed in West China Hospital from 2012 to 2016. TP53 mutation status in those p...

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Autores principales:	Caixia Jing, Yuhuan Zheng, Yu Feng, Xia Cao, Caigang Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ab9f3daa08dc457c84bf8fa103389d95
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spelling	oai:doaj.org-article:ab9f3daa08dc457c84bf8fa103389d952021-12-02T14:59:37ZPrognostic significance of p53, Sox11, and Pax5 co-expression in mantle cell lymphoma10.1038/s41598-021-91433-72045-2322https://doaj.org/article/ab9f3daa08dc457c84bf8fa103389d952021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91433-7https://doaj.org/toc/2045-2322Abstract Mantle cell lymphoma (MCL) is a relatively rare subtype of non-Hodgkin’s lymphoma. To identify molecular biomarkers in MCL, we performed immunohistochemistry tissue arrays using biopsies from 64 MCL patients diagnosed in West China Hospital from 2012 to 2016. TP53 mutation status in those patients was also examined by sequencing. The sequencing results showed TP53 mutations were highly heterogeneous in MCL. We identified four novel TP53 mutations in MCL: P151R, G199R, V218E, and G325R. The MCL patients with TP53 mutations had inferior progression-free survival (PFS, p = 0.002) and overall survival (OS, p = 0.011). Tissue array results showed the expression of p53, Sox11, or Pax5 alone did not correlate with the patient PFS and OS. However, the MCL patients with triple-positive expression of p53/Sox11/Pax5 had inferior PFS (p = 0.008) and OS (p = 0.002). Such risk stratification was independent to the mantle cell lymphoma international prognostic index (MIPI), Ki-67 value, and TP53 mutation status of the patients. The triple-positive patients might represent a subtype of high-risk MCL. Our findings might indicate a novel way to stratify MCL and predict patients’ prognosis.Caixia JingYuhuan ZhengYu FengXia CaoCaigang XuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Caixia Jing Yuhuan Zheng Yu Feng Xia Cao Caigang Xu Prognostic significance of p53, Sox11, and Pax5 co-expression in mantle cell lymphoma
description	Abstract Mantle cell lymphoma (MCL) is a relatively rare subtype of non-Hodgkin’s lymphoma. To identify molecular biomarkers in MCL, we performed immunohistochemistry tissue arrays using biopsies from 64 MCL patients diagnosed in West China Hospital from 2012 to 2016. TP53 mutation status in those patients was also examined by sequencing. The sequencing results showed TP53 mutations were highly heterogeneous in MCL. We identified four novel TP53 mutations in MCL: P151R, G199R, V218E, and G325R. The MCL patients with TP53 mutations had inferior progression-free survival (PFS, p = 0.002) and overall survival (OS, p = 0.011). Tissue array results showed the expression of p53, Sox11, or Pax5 alone did not correlate with the patient PFS and OS. However, the MCL patients with triple-positive expression of p53/Sox11/Pax5 had inferior PFS (p = 0.008) and OS (p = 0.002). Such risk stratification was independent to the mantle cell lymphoma international prognostic index (MIPI), Ki-67 value, and TP53 mutation status of the patients. The triple-positive patients might represent a subtype of high-risk MCL. Our findings might indicate a novel way to stratify MCL and predict patients’ prognosis.
format	article
author	Caixia Jing Yuhuan Zheng Yu Feng Xia Cao Caigang Xu
author_facet	Caixia Jing Yuhuan Zheng Yu Feng Xia Cao Caigang Xu
author_sort	Caixia Jing
title	Prognostic significance of p53, Sox11, and Pax5 co-expression in mantle cell lymphoma
title_short	Prognostic significance of p53, Sox11, and Pax5 co-expression in mantle cell lymphoma
title_full	Prognostic significance of p53, Sox11, and Pax5 co-expression in mantle cell lymphoma
title_fullStr	Prognostic significance of p53, Sox11, and Pax5 co-expression in mantle cell lymphoma
title_full_unstemmed	Prognostic significance of p53, Sox11, and Pax5 co-expression in mantle cell lymphoma
title_sort	prognostic significance of p53, sox11, and pax5 co-expression in mantle cell lymphoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ab9f3daa08dc457c84bf8fa103389d95
work_keys_str_mv	AT caixiajing prognosticsignificanceofp53sox11andpax5coexpressioninmantlecelllymphoma AT yuhuanzheng prognosticsignificanceofp53sox11andpax5coexpressioninmantlecelllymphoma AT yufeng prognosticsignificanceofp53sox11andpax5coexpressioninmantlecelllymphoma AT xiacao prognosticsignificanceofp53sox11andpax5coexpressioninmantlecelllymphoma AT caigangxu prognosticsignificanceofp53sox11andpax5coexpressioninmantlecelllymphoma
_version_	1718389223326744576

Prognostic significance of p53, Sox11, and Pax5 co-expression in mantle cell lymphoma

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