Synthesis of a novel ternary ZIF-8/GO/MgFe2O4 nanocomposite and its application in drug delivery

Abstract In recent year, metal–organic frameworks (MOFs) have been displayed to be a category of promising drug delivery systems because of their crystalline structure, the potential of further functionality, and high porosity. In this research, graphene oxide was synthesized from pure graphite via...

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Autores principales:	Saleheh Sanaei-Rad, Mohammad Ali Ghasemzadeh, Seyyed Mohammad Hossein Razavian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/abaa50f36efc44e181d0aaa24bd362cc
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spelling	oai:doaj.org-article:abaa50f36efc44e181d0aaa24bd362cc2021-12-02T17:27:19ZSynthesis of a novel ternary ZIF-8/GO/MgFe2O4 nanocomposite and its application in drug delivery10.1038/s41598-021-98133-22045-2322https://doaj.org/article/abaa50f36efc44e181d0aaa24bd362cc2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98133-2https://doaj.org/toc/2045-2322Abstract In recent year, metal–organic frameworks (MOFs) have been displayed to be a category of promising drug delivery systems because of their crystalline structure, the potential of further functionality, and high porosity. In this research, graphene oxide was synthesized from pure graphite via hummer method and then MgFe2O4 nanoparticles was incorporated into the synthesized ZIF-8 metal–organic frameworks which followed with loading on the surfaces of graphene oxide. In continue, tetracycline as an antibiotic drug was loaded on the surfaces and the cavities of the prepared nanocomposite. The outcomes of this research revealed that 90% of the tetracycline was loaded on the synthesized ZIF-8/GO/MgFe2O4 nanostructure. Next, drug release was done at pH: 5 and pH: 7.4 within 3 days, resulting about 88% and 92% release of the tetracycline, respectively. With using different spectroscopic methods like X-ray crystallography (XRD), scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDX/Mapping), Fourier transform infrared (FTIR), thermalgravimetric analysis (TGA), and Brunauer–Emmett–Teller (BET), the structure of synthesized materials was confirmed. Furthermore, the antibiotic activity of tetracycline trapped into the ZIF-8/GO/MgFe2O4 was evaluated by agar-well diffusion method on both gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria, which showed good antibacterial results.Saleheh Sanaei-RadMohammad Ali GhasemzadehSeyyed Mohammad Hossein RazavianNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Saleheh Sanaei-Rad Mohammad Ali Ghasemzadeh Seyyed Mohammad Hossein Razavian Synthesis of a novel ternary ZIF-8/GO/MgFe2O4 nanocomposite and its application in drug delivery
description	Abstract In recent year, metal–organic frameworks (MOFs) have been displayed to be a category of promising drug delivery systems because of their crystalline structure, the potential of further functionality, and high porosity. In this research, graphene oxide was synthesized from pure graphite via hummer method and then MgFe2O4 nanoparticles was incorporated into the synthesized ZIF-8 metal–organic frameworks which followed with loading on the surfaces of graphene oxide. In continue, tetracycline as an antibiotic drug was loaded on the surfaces and the cavities of the prepared nanocomposite. The outcomes of this research revealed that 90% of the tetracycline was loaded on the synthesized ZIF-8/GO/MgFe2O4 nanostructure. Next, drug release was done at pH: 5 and pH: 7.4 within 3 days, resulting about 88% and 92% release of the tetracycline, respectively. With using different spectroscopic methods like X-ray crystallography (XRD), scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDX/Mapping), Fourier transform infrared (FTIR), thermalgravimetric analysis (TGA), and Brunauer–Emmett–Teller (BET), the structure of synthesized materials was confirmed. Furthermore, the antibiotic activity of tetracycline trapped into the ZIF-8/GO/MgFe2O4 was evaluated by agar-well diffusion method on both gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria, which showed good antibacterial results.
format	article
author	Saleheh Sanaei-Rad Mohammad Ali Ghasemzadeh Seyyed Mohammad Hossein Razavian
author_facet	Saleheh Sanaei-Rad Mohammad Ali Ghasemzadeh Seyyed Mohammad Hossein Razavian
author_sort	Saleheh Sanaei-Rad
title	Synthesis of a novel ternary ZIF-8/GO/MgFe2O4 nanocomposite and its application in drug delivery
title_short	Synthesis of a novel ternary ZIF-8/GO/MgFe2O4 nanocomposite and its application in drug delivery
title_full	Synthesis of a novel ternary ZIF-8/GO/MgFe2O4 nanocomposite and its application in drug delivery
title_fullStr	Synthesis of a novel ternary ZIF-8/GO/MgFe2O4 nanocomposite and its application in drug delivery
title_full_unstemmed	Synthesis of a novel ternary ZIF-8/GO/MgFe2O4 nanocomposite and its application in drug delivery
title_sort	synthesis of a novel ternary zif-8/go/mgfe2o4 nanocomposite and its application in drug delivery
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/abaa50f36efc44e181d0aaa24bd362cc
work_keys_str_mv	AT salehehsanaeirad synthesisofanovelternaryzif8gomgfe2o4nanocompositeanditsapplicationindrugdelivery AT mohammadalighasemzadeh synthesisofanovelternaryzif8gomgfe2o4nanocompositeanditsapplicationindrugdelivery AT seyyedmohammadhosseinrazavian synthesisofanovelternaryzif8gomgfe2o4nanocompositeanditsapplicationindrugdelivery
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Synthesis of a novel ternary ZIF-8/GO/MgFe2O4 nanocomposite and its application in drug delivery

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