Conditional control of RNA-guided nucleic acid cleavage and gene editing

Constituitively active CRISPR systems have the risk of adverse off-target effects. Here the authors use chemical masking and activation of gRNA to control activity.

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Autores principales:	Shao-Ru Wang, Ling-Yu Wu, Hai-Yan Huang, Wei Xiong, Jian Liu, Lai Wei, Ping Yin, Tian Tian, Xiang Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/abb11b11237b4e71b1e2cf456319a32a
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spelling	oai:doaj.org-article:abb11b11237b4e71b1e2cf456319a32a2021-12-02T17:31:39ZConditional control of RNA-guided nucleic acid cleavage and gene editing10.1038/s41467-019-13765-32041-1723https://doaj.org/article/abb11b11237b4e71b1e2cf456319a32a2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13765-3https://doaj.org/toc/2041-1723Constituitively active CRISPR systems have the risk of adverse off-target effects. Here the authors use chemical masking and activation of gRNA to control activity.Shao-Ru WangLing-Yu WuHai-Yan HuangWei XiongJian LiuLai WeiPing YinTian TianXiang ZhouNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shao-Ru Wang Ling-Yu Wu Hai-Yan Huang Wei Xiong Jian Liu Lai Wei Ping Yin Tian Tian Xiang Zhou Conditional control of RNA-guided nucleic acid cleavage and gene editing
description	Constituitively active CRISPR systems have the risk of adverse off-target effects. Here the authors use chemical masking and activation of gRNA to control activity.
format	article
author	Shao-Ru Wang Ling-Yu Wu Hai-Yan Huang Wei Xiong Jian Liu Lai Wei Ping Yin Tian Tian Xiang Zhou
author_facet	Shao-Ru Wang Ling-Yu Wu Hai-Yan Huang Wei Xiong Jian Liu Lai Wei Ping Yin Tian Tian Xiang Zhou
author_sort	Shao-Ru Wang
title	Conditional control of RNA-guided nucleic acid cleavage and gene editing
title_short	Conditional control of RNA-guided nucleic acid cleavage and gene editing
title_full	Conditional control of RNA-guided nucleic acid cleavage and gene editing
title_fullStr	Conditional control of RNA-guided nucleic acid cleavage and gene editing
title_full_unstemmed	Conditional control of RNA-guided nucleic acid cleavage and gene editing
title_sort	conditional control of rna-guided nucleic acid cleavage and gene editing
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/abb11b11237b4e71b1e2cf456319a32a
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Conditional control of RNA-guided nucleic acid cleavage and gene editing

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