Genetic variations of DNA bindings of FOXA1 and co-factors in breast cancer susceptibility

The identification of transcription factors (TFs) whose binding sites are affected by risk genetic variants remains crucial. Here, the authors develop a statistical framework to analyse ChIP-seq and GWAS data, identify 22 breast cancer risk-associated TFs and a core TF-transcriptional network for FO...

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Autores principales:	Wanqing Wen, Zhishan Chen, Jiandong Bao, Quan Long, Xiao-ou Shu, Wei Zheng, Xingyi Guo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/abb3d8fa43c245a99dfc68464a409310
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spelling	oai:doaj.org-article:abb3d8fa43c245a99dfc68464a4093102021-12-02T17:25:35ZGenetic variations of DNA bindings of FOXA1 and co-factors in breast cancer susceptibility10.1038/s41467-021-25670-92041-1723https://doaj.org/article/abb3d8fa43c245a99dfc68464a4093102021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25670-9https://doaj.org/toc/2041-1723The identification of transcription factors (TFs) whose binding sites are affected by risk genetic variants remains crucial. Here, the authors develop a statistical framework to analyse ChIP-seq and GWAS data, identify 22 breast cancer risk-associated TFs and a core TF-transcriptional network for FOXA1 and co-factors.Wanqing WenZhishan ChenJiandong BaoQuan LongXiao-ou ShuWei ZhengXingyi GuoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wanqing Wen Zhishan Chen Jiandong Bao Quan Long Xiao-ou Shu Wei Zheng Xingyi Guo Genetic variations of DNA bindings of FOXA1 and co-factors in breast cancer susceptibility
description	The identification of transcription factors (TFs) whose binding sites are affected by risk genetic variants remains crucial. Here, the authors develop a statistical framework to analyse ChIP-seq and GWAS data, identify 22 breast cancer risk-associated TFs and a core TF-transcriptional network for FOXA1 and co-factors.
format	article
author	Wanqing Wen Zhishan Chen Jiandong Bao Quan Long Xiao-ou Shu Wei Zheng Xingyi Guo
author_facet	Wanqing Wen Zhishan Chen Jiandong Bao Quan Long Xiao-ou Shu Wei Zheng Xingyi Guo
author_sort	Wanqing Wen
title	Genetic variations of DNA bindings of FOXA1 and co-factors in breast cancer susceptibility
title_short	Genetic variations of DNA bindings of FOXA1 and co-factors in breast cancer susceptibility
title_full	Genetic variations of DNA bindings of FOXA1 and co-factors in breast cancer susceptibility
title_fullStr	Genetic variations of DNA bindings of FOXA1 and co-factors in breast cancer susceptibility
title_full_unstemmed	Genetic variations of DNA bindings of FOXA1 and co-factors in breast cancer susceptibility
title_sort	genetic variations of dna bindings of foxa1 and co-factors in breast cancer susceptibility
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/abb3d8fa43c245a99dfc68464a409310
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Genetic variations of DNA bindings of FOXA1 and co-factors in breast cancer susceptibility

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