Genetic variations of DNA bindings of FOXA1 and co-factors in breast cancer susceptibility

Genetic variations of DNA bindings of FOXA1 and co-factors in breast cancer susceptibility

The identification of transcription factors (TFs) whose binding sites are affected by risk genetic variants remains crucial. Here, the authors develop a statistical framework to analyse ChIP-seq and GWAS data, identify 22 breast cancer risk-associated TFs and a core TF-transcriptional network for FO...

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Autores principales: Wanqing Wen, Zhishan Chen, Jiandong Bao, Quan Long, Xiao-ou Shu, Wei Zheng, Xingyi Guo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/abb3d8fa43c245a99dfc68464a409310
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