DIAGNOSTIC VALUE OF BARIUM ENEMA IN HIRSCHSPRUNG S DISEASE

BACKGROUND AND OBJECTIVE: Hirschsprungs disease (HD) is a congenital defect in pediatric patients, which is manifested by bowel obstruction in neonates or constipation in children. The gold standard of diagnosis is absence of ganglionic cells in myenteric neural plexus and submucosa of bowel. With r...

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Autores principales:	H Karami, AR Alamsahebpour, M Ghasemi, M Khademloo
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2008
Materias:	hirschsprungs disease sensitivity specificity barium enema rectal biopsy Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/abbd4a411f3c402bba5c40fc219199ec
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spelling	oai:doaj.org-article:abbd4a411f3c402bba5c40fc219199ec2021-11-10T09:07:19ZDIAGNOSTIC VALUE OF BARIUM ENEMA IN HIRSCHSPRUNG S DISEASE1561-41072251-7170https://doaj.org/article/abbd4a411f3c402bba5c40fc219199ec2008-04-01T00:00:00Zhttp://jbums.org/article-1-2484-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Hirschsprungs disease (HD) is a congenital defect in pediatric patients, which is manifested by bowel obstruction in neonates or constipation in children. The gold standard of diagnosis is absence of ganglionic cells in myenteric neural plexus and submucosa of bowel. With regard to barium enema is a simple, less invasive and more available method than rectal biopsy, diagnostic evaluation of barium enema compared with rectal biopsy (as a diagnostic method) in HD is important. METHODS: In a cross-sectional study, 84 children with clinical manifestations of HD that referred to Boo-Ali Sina hospital of Sari, Iran were assessed from 2004 through 2007. Barium enema and rectal biopsy were carried out for all cases. Patients divided into three age groups as follows: under 1 month, 1- 12 months, more than 12 months. Patient with previous history of anorectal surgery and negative pathology of HD excluded from the study. Sensitivity, specificity, positive predictive value and negative predictive value of barium enema were calculated for identifying of the HD. FINDINGS: From 84 studied children, 28(33.3%) were girl. The mean age of the children was 26.1 months. The sensitivity, specificity, positive predictive value and negative predictive value of barium enema for diagnosis of the HD were 63.5%, 78.1%, 82.5%, and 56.8%, respectively. Diagnostic value of barium enema was calculated according to age groups mentioned above, that there were significant differences among them (p<0.05). CONCLUSION: The results of the study showed that the validity of barium enema for identifying of the HD is completely age related. This validity in specificity and positive predictive value are more significant than in sensitivity and negative predictive value. Therefore, it is recommended considering all three aspects of clinical manifestations, barium enema and rectal biopsy in diagnosis of HD. Of course, the diagnostic value is related to rectal biopsy.H Karami,AR Alamsahebpour,M Ghasemi,M KhademlooBabol University of Medical Sciencesarticlehirschsprungs diseasesensitivityspecificitybarium enemarectal biopsyMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 10, Iss 1, Pp 54-59 (2008)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	hirschsprungs disease sensitivity specificity barium enema rectal biopsy Medicine R Medicine (General) R5-920
spellingShingle	hirschsprungs disease sensitivity specificity barium enema rectal biopsy Medicine R Medicine (General) R5-920 H Karami, AR Alamsahebpour, M Ghasemi, M Khademloo DIAGNOSTIC VALUE OF BARIUM ENEMA IN HIRSCHSPRUNG S DISEASE
description	BACKGROUND AND OBJECTIVE: Hirschsprungs disease (HD) is a congenital defect in pediatric patients, which is manifested by bowel obstruction in neonates or constipation in children. The gold standard of diagnosis is absence of ganglionic cells in myenteric neural plexus and submucosa of bowel. With regard to barium enema is a simple, less invasive and more available method than rectal biopsy, diagnostic evaluation of barium enema compared with rectal biopsy (as a diagnostic method) in HD is important. METHODS: In a cross-sectional study, 84 children with clinical manifestations of HD that referred to Boo-Ali Sina hospital of Sari, Iran were assessed from 2004 through 2007. Barium enema and rectal biopsy were carried out for all cases. Patients divided into three age groups as follows: under 1 month, 1- 12 months, more than 12 months. Patient with previous history of anorectal surgery and negative pathology of HD excluded from the study. Sensitivity, specificity, positive predictive value and negative predictive value of barium enema were calculated for identifying of the HD. FINDINGS: From 84 studied children, 28(33.3%) were girl. The mean age of the children was 26.1 months. The sensitivity, specificity, positive predictive value and negative predictive value of barium enema for diagnosis of the HD were 63.5%, 78.1%, 82.5%, and 56.8%, respectively. Diagnostic value of barium enema was calculated according to age groups mentioned above, that there were significant differences among them (p<0.05). CONCLUSION: The results of the study showed that the validity of barium enema for identifying of the HD is completely age related. This validity in specificity and positive predictive value are more significant than in sensitivity and negative predictive value. Therefore, it is recommended considering all three aspects of clinical manifestations, barium enema and rectal biopsy in diagnosis of HD. Of course, the diagnostic value is related to rectal biopsy.
format	article
author	H Karami, AR Alamsahebpour, M Ghasemi, M Khademloo
author_facet	H Karami, AR Alamsahebpour, M Ghasemi, M Khademloo
author_sort	H Karami,
title	DIAGNOSTIC VALUE OF BARIUM ENEMA IN HIRSCHSPRUNG S DISEASE
title_short	DIAGNOSTIC VALUE OF BARIUM ENEMA IN HIRSCHSPRUNG S DISEASE
title_full	DIAGNOSTIC VALUE OF BARIUM ENEMA IN HIRSCHSPRUNG S DISEASE
title_fullStr	DIAGNOSTIC VALUE OF BARIUM ENEMA IN HIRSCHSPRUNG S DISEASE
title_full_unstemmed	DIAGNOSTIC VALUE OF BARIUM ENEMA IN HIRSCHSPRUNG S DISEASE
title_sort	diagnostic value of barium enema in hirschsprung s disease
publisher	Babol University of Medical Sciences
publishDate	2008
url	https://doaj.org/article/abbd4a411f3c402bba5c40fc219199ec
work_keys_str_mv	AT hkarami diagnosticvalueofbariumenemainhirschsprungsdisease AT aralamsahebpour diagnosticvalueofbariumenemainhirschsprungsdisease AT mghasemi diagnosticvalueofbariumenemainhirschsprungsdisease AT mkhademloo diagnosticvalueofbariumenemainhirschsprungsdisease
_version_	1718440319333171200

DIAGNOSTIC VALUE OF BARIUM ENEMA IN HIRSCHSPRUNG S DISEASE

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