The cost effectiveness of pandemic influenza interventions: a pandemic severity based analysis.

<h4>Background</h4>The impact of a newly emerged influenza pandemic will depend on its transmissibility and severity. Understanding how these pandemic features impact on the effectiveness and cost effectiveness of alternative intervention strategies is important for pandemic planning.<...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	George J Milne, Nilimesh Halder, Joel K Kelso
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/abbd641b8ba248c98a29421298da4bda
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:abbd641b8ba248c98a29421298da4bda
record_format	dspace
spelling	oai:doaj.org-article:abbd641b8ba248c98a29421298da4bda2021-11-18T07:49:57ZThe cost effectiveness of pandemic influenza interventions: a pandemic severity based analysis.1932-620310.1371/journal.pone.0061504https://doaj.org/article/abbd641b8ba248c98a29421298da4bda2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23585906/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The impact of a newly emerged influenza pandemic will depend on its transmissibility and severity. Understanding how these pandemic features impact on the effectiveness and cost effectiveness of alternative intervention strategies is important for pandemic planning.<h4>Methods</h4>A cost effectiveness analysis of a comprehensive range of social distancing and antiviral drug strategies intended to mitigate a future pandemic was conducted using a simulation model of a community of ∼30,000 in Australia. Six pandemic severity categories were defined based on case fatality ratio (CFR), using data from the 2009/2010 pandemic to relate hospitalisation rates to CFR.<h4>Results</h4>Intervention strategies combining school closure with antiviral treatment and prophylaxis are the most cost effective strategies in terms of cost per life year saved (LYS) for all severity categories. The cost component in the cost per LYS ratio varies depending on pandemic severity: for a severe pandemic (CFR of 2.5%) the cost is ∼$9 k per LYS; for a low severity pandemic (CFR of 0.1%) this strategy costs ∼$58 k per LYS; for a pandemic with very low severity similar to the 2009 pandemic (CFR of 0.03%) the cost is ∼$155 per LYS. With high severity pandemics (CFR >0.75%) the most effective attack rate reduction strategies are also the most cost effective. During low severity pandemics costs are dominated by productivity losses due to illness and social distancing interventions, while for high severity pandemics costs are dominated by hospitalisation costs and productivity losses due to death.<h4>Conclusions</h4>The most cost effective strategies for mitigating an influenza pandemic involve combining sustained social distancing with the use of antiviral agents. For low severity pandemics the most cost effective strategies involve antiviral treatment, prophylaxis and short durations of school closure; while these are cost effective they are less effective than other strategies in reducing the infection rate.George J MilneNilimesh HalderJoel K KelsoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e61504 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q George J Milne Nilimesh Halder Joel K Kelso The cost effectiveness of pandemic influenza interventions: a pandemic severity based analysis.
description	<h4>Background</h4>The impact of a newly emerged influenza pandemic will depend on its transmissibility and severity. Understanding how these pandemic features impact on the effectiveness and cost effectiveness of alternative intervention strategies is important for pandemic planning.<h4>Methods</h4>A cost effectiveness analysis of a comprehensive range of social distancing and antiviral drug strategies intended to mitigate a future pandemic was conducted using a simulation model of a community of ∼30,000 in Australia. Six pandemic severity categories were defined based on case fatality ratio (CFR), using data from the 2009/2010 pandemic to relate hospitalisation rates to CFR.<h4>Results</h4>Intervention strategies combining school closure with antiviral treatment and prophylaxis are the most cost effective strategies in terms of cost per life year saved (LYS) for all severity categories. The cost component in the cost per LYS ratio varies depending on pandemic severity: for a severe pandemic (CFR of 2.5%) the cost is ∼$9 k per LYS; for a low severity pandemic (CFR of 0.1%) this strategy costs ∼$58 k per LYS; for a pandemic with very low severity similar to the 2009 pandemic (CFR of 0.03%) the cost is ∼$155 per LYS. With high severity pandemics (CFR >0.75%) the most effective attack rate reduction strategies are also the most cost effective. During low severity pandemics costs are dominated by productivity losses due to illness and social distancing interventions, while for high severity pandemics costs are dominated by hospitalisation costs and productivity losses due to death.<h4>Conclusions</h4>The most cost effective strategies for mitigating an influenza pandemic involve combining sustained social distancing with the use of antiviral agents. For low severity pandemics the most cost effective strategies involve antiviral treatment, prophylaxis and short durations of school closure; while these are cost effective they are less effective than other strategies in reducing the infection rate.
format	article
author	George J Milne Nilimesh Halder Joel K Kelso
author_facet	George J Milne Nilimesh Halder Joel K Kelso
author_sort	George J Milne
title	The cost effectiveness of pandemic influenza interventions: a pandemic severity based analysis.
title_short	The cost effectiveness of pandemic influenza interventions: a pandemic severity based analysis.
title_full	The cost effectiveness of pandemic influenza interventions: a pandemic severity based analysis.
title_fullStr	The cost effectiveness of pandemic influenza interventions: a pandemic severity based analysis.
title_full_unstemmed	The cost effectiveness of pandemic influenza interventions: a pandemic severity based analysis.
title_sort	cost effectiveness of pandemic influenza interventions: a pandemic severity based analysis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/abbd641b8ba248c98a29421298da4bda
work_keys_str_mv	AT georgejmilne thecosteffectivenessofpandemicinfluenzainterventionsapandemicseveritybasedanalysis AT nilimeshhalder thecosteffectivenessofpandemicinfluenzainterventionsapandemicseveritybasedanalysis AT joelkkelso thecosteffectivenessofpandemicinfluenzainterventionsapandemicseveritybasedanalysis AT georgejmilne costeffectivenessofpandemicinfluenzainterventionsapandemicseveritybasedanalysis AT nilimeshhalder costeffectivenessofpandemicinfluenzainterventionsapandemicseveritybasedanalysis AT joelkkelso costeffectivenessofpandemicinfluenzainterventionsapandemicseveritybasedanalysis
_version_	1718422931559677952

The cost effectiveness of pandemic influenza interventions: a pandemic severity based analysis.

Ejemplares similares