Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy

HuR is an RNA-binding protein that regulates myotube differentiation in vitro. Here, the authors show that the muscle-specific ablation of HuR in mice leads to enhanced endurance capacity and an increase in oxidative fibres by destabilising PGC1α-mRNA, and show that the mice are protected against ca...

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Autores principales:	Brenda Janice Sánchez, Anne-Marie K. Tremblay, Jean-Philippe Leduc-Gaudet, Derek T. Hall, Erzsebet Kovacs, Jennifer F. Ma, Souad Mubaid, Patricia L. Hallauer, Brittany L. Phillips, Katherine E. Vest, Anita H. Corbett, Dimitris L. Kontoyiannis, Sabah N. A. Hussain, Kenneth E. M. Hastings, Sergio Di Marco, Imed-Eddine Gallouzi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/abbd8d839dcd49f5a47e7010f27a777f
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spelling	oai:doaj.org-article:abbd8d839dcd49f5a47e7010f27a777f2021-12-02T17:02:03ZDepletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy10.1038/s41467-019-12186-62041-1723https://doaj.org/article/abbd8d839dcd49f5a47e7010f27a777f2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12186-6https://doaj.org/toc/2041-1723HuR is an RNA-binding protein that regulates myotube differentiation in vitro. Here, the authors show that the muscle-specific ablation of HuR in mice leads to enhanced endurance capacity and an increase in oxidative fibres by destabilising PGC1α-mRNA, and show that the mice are protected against cancer cachexiaBrenda Janice SánchezAnne-Marie K. TremblayJean-Philippe Leduc-GaudetDerek T. HallErzsebet KovacsJennifer F. MaSouad MubaidPatricia L. HallauerBrittany L. PhillipsKatherine E. VestAnita H. CorbettDimitris L. KontoyiannisSabah N. A. HussainKenneth E. M. HastingsSergio Di MarcoImed-Eddine GallouziNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brenda Janice Sánchez Anne-Marie K. Tremblay Jean-Philippe Leduc-Gaudet Derek T. Hall Erzsebet Kovacs Jennifer F. Ma Souad Mubaid Patricia L. Hallauer Brittany L. Phillips Katherine E. Vest Anita H. Corbett Dimitris L. Kontoyiannis Sabah N. A. Hussain Kenneth E. M. Hastings Sergio Di Marco Imed-Eddine Gallouzi Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy
description	HuR is an RNA-binding protein that regulates myotube differentiation in vitro. Here, the authors show that the muscle-specific ablation of HuR in mice leads to enhanced endurance capacity and an increase in oxidative fibres by destabilising PGC1α-mRNA, and show that the mice are protected against cancer cachexia
format	article
author	Brenda Janice Sánchez Anne-Marie K. Tremblay Jean-Philippe Leduc-Gaudet Derek T. Hall Erzsebet Kovacs Jennifer F. Ma Souad Mubaid Patricia L. Hallauer Brittany L. Phillips Katherine E. Vest Anita H. Corbett Dimitris L. Kontoyiannis Sabah N. A. Hussain Kenneth E. M. Hastings Sergio Di Marco Imed-Eddine Gallouzi
author_facet	Brenda Janice Sánchez Anne-Marie K. Tremblay Jean-Philippe Leduc-Gaudet Derek T. Hall Erzsebet Kovacs Jennifer F. Ma Souad Mubaid Patricia L. Hallauer Brittany L. Phillips Katherine E. Vest Anita H. Corbett Dimitris L. Kontoyiannis Sabah N. A. Hussain Kenneth E. M. Hastings Sergio Di Marco Imed-Eddine Gallouzi
author_sort	Brenda Janice Sánchez
title	Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy
title_short	Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy
title_full	Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy
title_fullStr	Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy
title_full_unstemmed	Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy
title_sort	depletion of hur in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/abbd8d839dcd49f5a47e7010f27a777f
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Depletion of HuR in murine skeletal muscle enhances exercise endurance and prevents cancer-induced muscle atrophy

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